Document Detail

Treatment of adenovirus infections in the immunocompromised host.
MedLine Citation:
PMID:  15248091     Owner:  NLM     Status:  MEDLINE    
Adenovirus infections are increasing as causes of morbidity and mortality in severely immunocompromised patients. The currently available antiviral agents, ribavirin and cidofovir, have yielded mixed results in case reports and small case series. Similar to cytomegalovirus disease, established adenovirus disease is often difficult to treat. Therapy may yield poor results, even when effective antiviral drugs are used. New strategies, including pre-emptive therapy, should be tested in prospective, clinical trials. New agents and adoptive transfer of specific T-cells to adenovirus might improve the current situation.
P Ljungman
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2004-07-10
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  23     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-23     Completed Date:  2004-10-28     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  583-8     Citation Subset:  IM    
Department of Haematology, Karolinska University Hospital/Huddinge, 14186 Stockholm, Sweden.
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MeSH Terms
Adenoviridae Infections / drug therapy*,  epidemiology*,  immunology
Antiviral Agents / therapeutic use*
Clinical Trials as Topic
Cytosine / analogs & derivatives*,  therapeutic use
Dose-Response Relationship, Drug
Drug Administration Schedule
Ganciclovir / therapeutic use
Hematopoietic Stem Cell Transplantation
Immunocompromised Host*
Organ Transplantation
Organophosphorus Compounds / therapeutic use
Ribavirin / therapeutic use
Severity of Illness Index
Transplantation Immunology
Treatment Outcome
Vidarabine / therapeutic use
Reg. No./Substance:
0/Antiviral Agents; 0/Organophosphonates; 0/Organophosphorus Compounds; 36791-04-5/Ribavirin; 5536-17-4/Vidarabine; 71-30-7/Cytosine; 82410-32-0/Ganciclovir; JIL713Q00N/cidofovir

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