Document Detail

Treatment of acute neuropsychiatric lupus with intravenous immunoglobulin (IVIG): a case report and review of the literature.
MedLine Citation:
PMID:  15662488     Owner:  NLM     Status:  MEDLINE    
Neuropsychiatric lupus can be difficult to diagnose, and little prospective data exists to help direct management. In this case report we describe the acute onset of symptoms of depression, mania, and psychosis and their complete resolution 48 h following a 5-day treatment course of intravenous immunoglobulin (IVIG) in a 20-year-old woman with systemic lupus erythematosus (SLE). We review the literature on IVIG for the management of neuropsychiatric lupus. We propose that when more toxic therapies are refused or symptoms do not remit with other treatments, IVIG should be considered in patients with neuropsychiatric lupus.
Aaron M Milstone; Kevin Meyers; Josephine Elia
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2005-01-21
Journal Detail:
Title:  Clinical rheumatology     Volume:  24     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-21     Completed Date:  2006-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  394-7     Citation Subset:  IM    
Children's Hospital of Philadelphia, CHOP North Room 1479, Philadelphia, PA 19104, USA.
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MeSH Terms
Acute Disease
Dose-Response Relationship, Drug
Drug Administration Schedule
Follow-Up Studies
Immunoglobulins, Intravenous / administration & dosage*
Lupus Vasculitis, Central Nervous System / diagnosis*,  drug therapy*
Risk Assessment
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Immunoglobulins, Intravenous

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