Document Detail

Treatment of acute myocardial infarction with sodium nitroprusside during 24 hours, followed by isosorbide dinitrate.
MedLine Citation:
PMID:  7034472     Owner:  NLM     Status:  MEDLINE    
In a controlled randomized study of 328 consecutive patients admitted within 24 hours after the onset of acute myocardial infarction, 163 patients received a sodium nitroprusside infusion during 24 hours, followed by six times a day 5 mg isosorbide dinitrate for seven days and 165 patients received a glucose 5% infusion. Excluded from the study were patients with either pulmonary edema and/or cardiogenic shock, two or more previous myocardial infarctions or a systolic blood pressure of less than 95 mmHg just before entering the study. Sodium nitroprusside was titrated in such a way that systolic blood pressure was kept between 95 and 105 mmHg. Standard medical treatment for both groups was the same. CK-MB was sampled every four hours until peak value was reached. Endpoint of the study was a significant reduction in mortality within a week after starting treatment.
J D Durrer; K I Lie; F J van Capelle
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta medica Scandinavica. Supplementum     Volume:  651     ISSN:  0365-463X     ISO Abbreviation:  Acta Med. Scand. Suppl.     Publication Date:  1981  
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370331     Medline TA:  Acta Med Scand Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  163     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Ferricyanides / administration & dosage*
Isosorbide Dinitrate / administration & dosage*
Myocardial Infarction / diagnosis,  drug therapy*
Nitroprusside / administration & dosage*
Reg. No./Substance:
0/Ferricyanides; 15078-28-1/Nitroprusside; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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