Document Detail

Treatment of acute massive pulmonary embolism by streptokinase during labour and delivery.
MedLine Citation:
PMID:  4539533     Owner:  NLM     Status:  MEDLINE    
A 29-year-old woman sustained an acute massive pulmonary embolism in the 32nd week of pregnancy. Rapid clinical improvement followed the use of streptokinase. Treatment was continued for 41 hours, including labour and the first three hours after delivery. There was slow but severe postpartum haemorrhage. Partial uterine atony occurred, and may have been due, at least in part, to fibrin degradation products arising from thrombolysis. No adverse effects were noted in the baby.Our experience suggests that streptokinase may be given during labour but that an oxytocic agent may be needed; and that reversal of fibrinolysis before delivery is best achieved by the use of aprotinin (Trasylol) rather than aminocaproic acid.
R J Hall; C Young; G C Sutton; S Cambell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  4     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1972 Dec 
Date Detail:
Created Date:  1973-03-07     Completed Date:  1973-03-07     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  647-9     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Aminocaproic Acids / therapeutic use
Aprotinin / therapeutic use
Fibrinolysis / drug effects
Obstetric Labor Complications*
Postpartum Hemorrhage / complications
Pregnancy Complications, Hematologic / drug therapy*
Pulmonary Embolism / complications,  drug therapy*
Streptokinase / therapeutic use*
Uterine Inertia / complications
Reg. No./Substance:
0/Aminocaproic Acids; 9087-70-1/Aprotinin; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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