Document Detail


Treatment of acute ischemic stroke.
MedLine Citation:
PMID:  17903844     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Acute ischemic stroke remains difficult to treat despite the advent of new therapies. The only approved medication to reverse its effects is recombinant tissue plasminogen activator administered intravenously within 3 hours of onset of stroke symptoms--an opportunity that does not often present itself. The principal drawback to thrombolytic therapy for acute ischemic stroke is a 3% to 6% occurrence of symptomatic cerebral hemorrhage. Although intra-arterial recombinant prourokinase also appears to be effective, it has not been approved by the Food and Drug Administration. Aspirin administered within 48 hours of stroke onset can prevent a few recurrent strokes and deaths. The efficacy of heparin and heparinoids in acute ischemic stroke has not been shown. Despite their theoretical attractiveness and laboratory results, neuroprotective agents have not proven effective in clinical trials. In view of current limitations on the ability to treat and reverse the effects of acute ischemic stroke, improved preventive measures in patients at risk for stroke are urgently needed.
Authors:
M J Alberts
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  10     ISSN:  1532-8511     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2007-10-01     Completed Date:  2007-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10-7     Citation Subset:  -    
Affiliation:
Department of Neurology, Northwestern University Medical School, Chicago, IL 60611, USA.
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