Document Detail

Treatment of acute infectious purpura fulminans with activated protein C.
MedLine Citation:
PMID:  16820663     Owner:  NLM     Status:  MEDLINE    
Infectious purpura fulminans is associated with high mortality and morbidity despite standard antimicrobial therapy. We report satisfactory clinical outcome in two children with sepsis associated purpura fulminans who were treated with activated protein C (APC). There is need for proper evaluation of the efficacy of this extremely expensive therapeutic modality by randomized controlled trials before it is made standard of care in childhood infectious purpura fulminans.
M R Lokeshwar; T Singhal; S V Udani; F N Kapadia
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Indian pediatrics     Volume:  43     ISSN:  0019-6061     ISO Abbreviation:  Indian Pediatr     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-07-05     Completed Date:  2006-09-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  535-8     Citation Subset:  IM    
Department of Pediatrics, P.D. Hinduja National Hospital and Research Center, Veer Savarkar Marg, Mumbai 400 016, India.
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MeSH Terms
Acute Disease
Anticoagulants / therapeutic use*
Blood Coagulation Factors / drug effects*
Child, Preschool
Protein C / therapeutic use*
Purpura, Schoenlein-Henoch / drug therapy*
Receptors, Cell Surface / drug effects*
Treatment Outcome*
Reg. No./Substance:
0/Anticoagulants; 0/Blood Coagulation Factors; 0/Protein C; 0/Receptors, Cell Surface; 0/activated protein C receptor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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