Document Detail

Treatment of acute bacterial peritonitis: a trial of imipenem/cilastatin against ampicillin-metronidazole-gentamicin.
MedLine Citation:
PMID:  3331045     Owner:  NLM     Status:  MEDLINE    
Imipenem/cilastatin at a dose of 0.5 g six hourly was compared to conventional combination therapy with ampicillin 0.5 g six hourly, metronidazole 0.5 g eight hourly and gentamicin 80 mg eight hourly (with dose adjustment by trough and peak serum levels) in the treatment of severe intra-abdominal infections. All antibiotics were given intravenously. Forty-five patients entered the trial. Of the 19 evaluable patients in the imipenem/cilastatin group, 16 were clinically cured with five microbiological successes and two failures. Of 24 evaluable patients in the combination group, 22 were clinically cured with one microbiological success and one failure. One patient in each group suffered an adverse effect. Patients in the I/C group tended to be older with more women and more severe infections. The origin of peritonitis was similar. I/C did not differ from combination therapy in efficacy or safety and was comparable in cost. However, I/C was easier to administer than combination therapy and there was no need for serum concentration monitoring.
D J Leaper; R H Kennedy; A Sutton; E Johnson; N Roberts
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of infectious diseases. Supplementum     Volume:  52     ISSN:  0300-8878     ISO Abbreviation:  Scand J Infect Dis Suppl     Publication Date:  1987  
Date Detail:
Created Date:  1988-08-18     Completed Date:  1988-08-18     Revised Date:  2009-10-28    
Medline Journal Info:
Nlm Unique ID:  0251025     Medline TA:  Scand J Infect Dis Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  7-10     Citation Subset:  IM    
University Department of Surgery, Southmead Hospital, Bristol, U.K.
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MeSH Terms
Aged, 80 and over
Ampicillin / administration & dosage
Anti-Bacterial Agents / therapeutic use*
Bacterial Infections / drug therapy*
Clinical Trials as Topic
Cyclopropanes / administration & dosage
Drug Combinations / administration & dosage
Drug Therapy, Combination
Gentamicins / administration & dosage
Metronidazole / administration & dosage
Middle Aged
Peritonitis / drug therapy*,  etiology
Random Allocation
Thienamycins / administration & dosage
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cyclopropanes; 0/Drug Combinations; 0/Gentamicins; 0/Thienamycins; 443-48-1/Metronidazole; 69-53-4/Ampicillin; 74431-23-5/Imipenem; 82009-34-5/Cilastatin; 92309-29-0/cilastatin, imipenem drug combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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