| Treatment of acne vulgaris with topical clindamycin phosphate: a double-blind study. | |
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MedLine Citation:
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PMID: 6453849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a double-blind study, 1% clindamycin phosphate in aqueous-alcohol vehicle was compared with the vehicle alone on the opposite side. Of 29 patients evaluated, the clindamycin-treated side was found to be better in 11, the placebo side was better in four, and both sides were improved in five. No benefit was found in the remaining nine patients. These results were not considered statistically significant. Following discontinuance of treatment a prominent flare was noted in 14 of 19 patients who had previously improved on one side or the other, and this was considered significant (p less than .05). One percent clindamycin phosphate in equal parts of alcohol and water is apparently beneficial for some, but not for all patients with inflammatory acne. |
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Authors:
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J D Guin |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: International journal of dermatology Volume: 20 ISSN: 0011-9059 ISO Abbreviation: Int. J. Dermatol. Publication Date: 1981 May |
Date Detail:
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Created Date: 1981-08-20 Completed Date: 1981-08-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0243704 Medline TA: Int J Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 286-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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drug therapy* Administration, Oral Administration, Topical Clindamycin / administration & dosage* Clinical Trials as Topic Double-Blind Method Humans |
| Chemical | |
Reg. No./Substance:
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18323-44-9/Clindamycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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