Document Detail

Treatment of acne vulgaris with the retinoic acid derivative Ro 11-1430. A controlled clinical trial against retinoic acid.
MedLine Citation:
PMID:  138608     Owner:  NLM     Status:  MEDLINE    
In a double-blind, randomized, group-comparative clinical trial, 31 patients with acne vulgaris received topical treatment for 6-8 weeks with a lotion containing either 0.05% retinoic acid or 0.1% of the retinoic acid derivative Ro 11-1430. The side-effects erythema, desquamation and burning were significantly less frequent with Ro 11-1430 than with retinoic acid. The treatments appeared to be approximately equally effective in reducing the number of acne elements, but due to the limited number of patients studied, the trial was admittedly not sufficient to detect differences with regard to therapeutic efficacy.
J Christiansen; P Holm; F Reymann
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Dermatologica     Volume:  153     ISSN:  0011-9075     ISO Abbreviation:  Dermatologica     Publication Date:  1976  
Date Detail:
Created Date:  1977-04-25     Completed Date:  1977-04-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0211607     Medline TA:  Dermatologica     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  172-6     Citation Subset:  IM    
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MeSH Terms
Acne Vulgaris / drug therapy*
Administration, Topical
Clinical Trials as Topic
Drug Eruptions
Drug Evaluation
Erythema / chemically induced
Tretinoin / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use
Vitamin A / analogs & derivatives*
Reg. No./Substance:
11103-57-4/Vitamin A; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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