Document Detail

Treatment of abdominal compartment syndrome in severe acute pancreatitis patients with traditional Chinese medicine.
MedLine Citation:
PMID:  18567089     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the therapeutic effect of traditional Chinese traditional medicines Da Cheng Qi Decoction (Timely-Purging and Yin-Preserving Decoction) and Glauber's salt combined with conservative measures on abdominal compartment syndrome (ACS) in severe acute pancreatitis (SAP) patients. METHODS: Eighty consecutive SAP patients, admitted for routine non-operative conservative treatment, were randomly divided into study group and control group (40 patients in each group). Patients in the study group received Da Cheng Qi Decoction enema for 2 h and external use of Glauber's salt, once a day for 7 d. Patients in the control group received normal saline (NS) enema. Routine non-operative conservative treatments included non-per os nutrition (NPON), gastrointestinal decompression, life support, total parenteral nutrition (TPN), continuous peripancreatic vascular pharmaceutical infusion and drug therapy. Intra-cystic pressure (ICP) of the two groups was measured during treatment. The effectiveness and outcomes of treatment were observed and APACHE II scores were applied in analysis. RESULTS: On days 4 and 5 of treatment, the ICP was lower in the study group than in the control group (P < 0.05). On days 3-5 of treatment, acute physiology and chronic health evaluation II (APACHE II) scores for the study and control groups were significantly different (P < 0.05). Both the effectiveness and outcome of the treatment with Da Cheng Qi Decoction on abdominalgia, burbulence relief time, ascites quantity, cyst formation rate and hospitalization time were quite different between the two groups (P < 0.05). The mortality rate for the two groups had no significant difference. CONCLUSION: Da Cheng Qi Decoction enema and external use of Glauber's salt combined with routine non-operative conservative treatment can decrease the intra-abdominal pressure (IAP) of SAP patients and have preventive and therapeutic effects on abdominal compartment syndrome of SAP.
Min-Jie Zhang; Guo-Lei Zhang; Wen-Bin Yuan; Jun Ni; Li-Feng Huang
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  14     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-20     Completed Date:  2008-10-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  3574-8     Citation Subset:  IM    
Department of General surgery, Affiliated Central Hospital of Huzhou Normal College, Huzhou 313000, Zhejiang Province, China.
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MeSH Terms
Abdominal Cavity / physiopathology
Acute Disease
Compartment Syndromes / etiology,  physiopathology,  therapy*
Drugs, Chinese Herbal / administration & dosage,  therapeutic use
Hypertension / etiology,  physiopathology,  therapy*
Medicine, Chinese Traditional*
Middle Aged
Multiple Organ Failure / etiology,  physiopathology,  therapy*
Pancreatitis / complications*
Treatment Outcome
Reg. No./Substance:
0/Da-Cheng-Qi-Tang; 0/Drugs, Chinese Herbal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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