Document Detail


Treatment of Wilson's disease with zinc. II. Validation of oral 64copper with copper balance.
MedLine Citation:
PMID:  3799705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of zinc as a therapeutic agent to control copper balance in Wilson's disease patients has been previously documented with balance studies. In an attempt to develop a simpler and faster tool for evaluating the adequacy of zinc therapy, a technique that measures the uptake into blood of a small oral dose of 64copper was studied in conjunction with copper balance. The mean peak 64copper uptake into blood of nine Wilson's disease patients on D-penicillamine, trien, or no medication was 6.04 +/- 2.74%, comparable with normal controls. Seven patients on zinc therapy had a markedly and significantly reduced mean uptake of 0.79 +/- 1.05% after treatment. The data demonstrate that the prevention of copper uptake into blood in Wilson's disease patients by zinc therapy can be evaluated by 64copper uptake and that peak uptakes of less than 1% occur in patients with neutral or negative copper balance.
Authors:
G M Hill; G J Brewer; J E Juni; A S Prasad; R D Dick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  292     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-02-03     Completed Date:  1987-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  344-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acetic Acid
Acetic Acids / therapeutic use
Adult
Copper / diagnostic use,  metabolism*
Drug Evaluation
Hepatolenticular Degeneration / drug therapy*
Homeostasis
Humans
Radioisotopes / diagnostic use
Sulfates / therapeutic use
Zinc / administration & dosage,  therapeutic use*
Zinc Sulfate
Grant Support
ID/Acronym/Agency:
AM 31401/AM/NIADDK NIH HHS; HL 16008/HL/NHLBI NIH HHS; R01-AM 26050/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Acetic Acids; 0/Radioisotopes; 0/Sulfates; 64-19-7/Acetic Acid; 7440-50-8/Copper; 7440-66-6/Zinc; 7733-02-0/Zinc Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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