Document Detail


Treatment of Vogt-Koyanagi- Harada's disease during pregnancy.
MedLine Citation:
PMID:  11313051     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Caution should be exercised in treating patients with autoimmune diseases during pregnancy. CASES: We successfully treated three cases of Vogt-Koyanagi-Harada's disease (VKH disease) during pregnancy. OBSERVATIONS: In the second trimester (14-27 weeks) of 1 patient, inflammation was mild and could be treated by topical corticosteroid. There is the possibility that her immune response had been modified by pregnancy. Systemic corticosteroid in a high dose was administered to the two cases in the second and third trimesters of pregnancy (28-41 weeks). The severity of inflammation in these 2 patients was similar to that in nonpregnant women. Inflammation subsided immediately without recurrence in all cases. No abnormality was found during the deliveries or in the babies. CONCLUSIONS: Treatment for VKH disease during pregnancy should be chosen according to the severity of inflammation, the stage of pregnancy, and the maternal and fetal conditions.
Authors:
N Miyata; M Sugita; S Nakamura; K Isobe; H Matoba; K Tsuda; K Tanaka; S Ohno
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Japanese journal of ophthalmology     Volume:  45     ISSN:  0021-5155     ISO Abbreviation:  Jpn. J. Ophthalmol.     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2001-04-23     Completed Date:  2001-06-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0044652     Medline TA:  Jpn J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-80     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Yokohama City University School of Medicine, Yokahama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fluorescein Angiography
Fundus Oculi
Gestational Age
Glucocorticoids / therapeutic use
Humans
Infusions, Intravenous
Prednisolone / therapeutic use
Pregnancy
Pregnancy Complications / diagnosis,  drug therapy*
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Uveomeningoencephalitic Syndrome / diagnosis,  drug therapy*
Chemical
Reg. No./Substance:
0/Glucocorticoids; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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