Document Detail

Treatment update in small-cell lung cancer: from limited to extensive disease.
MedLine Citation:
PMID:  23139116     Owner:  NLM     Status:  MEDLINE    
Small-cell lung cancers are aggressive tumors, often discovered with widespread metastases that include brain involvement. For patients with limited-stage disease, the standard of care is platinum-doublet chemotherapy (often etoposide) with concurrent radiation. Concurrent chemoradiotherapy can be difficult when given upfront, sometimes preventing on-time completion of later chemotherapy cycles. Recent data support giving concurrent chemoradiotherapy following 1 or 2 cycles of chemotherapy alone. For patients with extensive disease, chemotherapy alone remains the standard of care. For patients with limited or extensive disease who achieve clinical benefit from primary therapy, consideration of prophylactic cranial radiation should be made. Despite aggressive use of these treatments, most patients will have life-threatening disease return, sometimes very soon after finishing treatment. For those patients who are candidates for additional systemic treatment, several single-agent options exist, such as topotecan, paclitaxel, or even consideration of retreating with the same initial regimen depending on how effective it was. All patients with SCLC should be considered for clinical trials, because this remains our greatest hope for finding more effective therapies.
David R Spigel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current treatment options in oncology     Volume:  13     ISSN:  1534-6277     ISO Abbreviation:  Curr Treat Options Oncol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-05-24     Revised Date:  2013-07-25    
Medline Journal Info:
Nlm Unique ID:  100900946     Medline TA:  Curr Treat Options Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-15     Citation Subset:  IM    
Lung Cancer Research Program, Sarah Cannon Research Institute, 250 25th Avenue North, Suite 110, Nashville, TN 37203, USA.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols*
Carcinoma, Small Cell* / drug therapy,  pathology,  radiotherapy
Cisplatin / administration & dosage
Clinical Trials as Topic
Combined Modality Therapy
Etoposide / administration & dosage
Lung Neoplasms* / drug therapy,  pathology,  radiotherapy
Neoplasm Metastasis
Neoplasm Staging
Paclitaxel / administration & dosage
Small Cell Lung Carcinoma* / drug therapy,  pathology,  radiotherapy
Topotecan / administration & dosage
Reg. No./Substance:
123948-87-8/Topotecan; 15663-27-1/Cisplatin; 33069-62-4/Paclitaxel; 33419-42-0/Etoposide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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