Document Detail

Treatment of ulcerative necrobiosis lipoidica with topical calcineurin inhibitor: case report and literature review.
MedLine Citation:
PMID:  23149208     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ulcerative necrobiosis lipoidica (UNL) is an uncommon disease, which is frequently recalcitrant to available therapies. It is characterized by well-defined, ulcerated plaques with indurated borders and atrophic centers. Multiple therapeutic options have been described, with variable success rates.
OBJECTIVE: To report the efficacy of using topical tacrolimus in treating UNL.
METHOD: Topical tacrolimus was used in the treatment of two patients with UNL.
RESULT: Topical tacrolimus is effective in treating UNL.
CONCLUSION: Topical tacrolimus is a reasonably effective choice in treating UNL.
Yousef Binamer; Laura Sowerby; Therese El-Helou
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of cutaneous medicine and surgery     Volume:  16     ISSN:  1203-4754     ISO Abbreviation:  J Cutan Med Surg     Publication Date:    2012 Nov-Dec
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-04-16     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9614685     Medline TA:  J Cutan Med Surg     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  458-61     Citation Subset:  IM    
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MeSH Terms
Administration, Cutaneous
Aged, 80 and over
Calcineurin / antagonists & inhibitors*
Immunosuppressive Agents / administration & dosage,  therapeutic use*
Necrobiosis Lipoidica / complications,  drug therapy*
Skin Ulcer / complications,  drug therapy
Tacrolimus / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Immunosuppressive Agents; EC; WM0HAQ4WNM/Tacrolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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