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A treatment trial of vitamin D supplementation in breast-fed infants: Universal supplementation is not necessary for rickets prevention in Southern Louisiana.
MedLine Citation:
PMID:  20724336     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
This study was conducted to determine if vitamin D supplementation is required to prevent rickets in breast-fed infants. Breast-feeding rates are increasing, and there are concerns about whether the vitamin D content of breast milk is sufficient. There are a few treatment trials of vitamin D supplementation in breast-fed infants; these were conducted in northern climates. The authors therefore performed a prospective clinical trial comparing vitamin D supplementation with placebo as control in southern Louisiana. Blood samples and questionnaires were collected at birth, 2, 4, and 6 months of age. There were no cases of rickets observed, and no differences in alkaline phosphatase levels between groups. Thus, there was no evidence that vitamin D supplementation reduced rickets risk in the authors' study population. This suggests that the current recommendations for universal vitamin D supplementation of breast-fed infants throughout the United States may need to be revised.
Authors:
Tulasi Ponnapakkam; Elease Bradford; Robert Gensure
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-19
Journal Detail:
Title:  Clinical pediatrics     Volume:  49     ISSN:  1938-2707     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1053-60     Citation Subset:  AIM; IM    
Affiliation:
Ochsner Clinic Foundation, New Orleans, LA 70121, USA. tponnapakkam@ochsner.org
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