Document Detail

Treatment solutions are unclear for perimegaprosthetic infections.
MedLine Citation:
PMID:  23423621     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Infection about a megaprosthesis is a dreaded complication. Treatment options vary from débridement alone to staged revisions, arthrodesis, and amputation. Indications for how to treat this complication are unclear.
QUESTIONS/PURPOSES: We therefore determined (1) the incidence of perimegaprosthetic infections, (2) the methods of treatment, (3) the number of patients who failed their original treatment plan, and (4) the characteristics of the infection.
METHODS: We retrospectively identified 291 patients who had megaprostheses implanted between 2001 and 2011 and identified all those surgically treated for a perimegaprosthetic infection during that time. We defined a treatment failure as any unplanned reoperation or death due to uncontrolled infection. All patients with failure had a minimum followup of 1 year (mean, 3.3 years; range, 1-8 years).
RESULTS: Of the 291 patients, 31 (11%) had subsequent infections. Surgical management varied among irrigation and débridement (n=15), single-stage revisions (n=11), two-stage revisions (n=4), and amputations (n=1). Sixteen patients failed their original treatment plan: 13 required additional surgery and three died. Infections were mostly chronic and single organism with five being methicillin-resistant Staphylococcus aureus.
CONCLUSIONS: An 11% incidence of perimegaprosthetic infections is consistent with the increased risk of infection seen in other studies. A variety of surgical methods were employed at our institution and by those contributing to the literature without clear evidence of superiority of one method over another. Given the complicated medical and surgical histories of these patients, individualization in decision making is necessary.
LEVEL OF EVIDENCE: Level III, therapeutic study. See Instructions for Authors for a complete description of levels of evidence.
Lisa B Ercolano; Tyson Christensen; Richard McGough; Kurt Weiss
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  471     ISSN:  1528-1132     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-16     Completed Date:  2013-11-25     Revised Date:  2014-10-12    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3204-13     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use*
Middle Aged
Prostheses and Implants / adverse effects*
Prosthesis-Related Infections / drug therapy,  epidemiology*,  surgery,  therapy*
Retrospective Studies
Therapeutic Irrigation
Treatment Failure
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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