Document Detail

Treatment of small hepatocellular carcinomas with US-guided high-intensity focused ultrasound.
MedLine Citation:
PMID:  21645963     Owner:  NLM     Status:  MEDLINE    
High-intensity focused ultrasound (HIFU) is a noninvasive method that can cause complete coagulation necrosis without requiring the insertion of any instruments. The purpose of this study was to evaluate the safety and efficacy of HIFU treatment for small liver cancers without performing transcatheter arterial chemoembolization (TACE) or rib resection. HIFU ablation was performed without rib resection or the aid of TACE or percutaneous ethanol injection (PEI) in 12 patients with hepatocelullar carcinoma. The HIFU system (Chongqing Haifu Tech, Chongqing, China) was used under ultrasound guidance. All 12 patients completed the treatment without experiencing any adverse events. Complete coagulation was achieved by applying the sonications from the intercostal space when the tumor was located in the right lobe. After treatment, serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) levels were significantly higher than the baseline values; these levels recovered within 1 week. C-reactive protein (CRP) levels increased 1 week after treatment but decreased within 1 month. An epidural anesthetic provided sufficient pain suppression during the procedure. Edema of the subcutaneous tissue was detected in five cases, but the edema disappeared within 1 month. None of the patients developed acute hepatic failure, liver abscess or renal dysfunction. In conclusion, HIFU is effective for the treatment of patients with small liver cancer.
Hiroyuki Fukuda; Ryu Ito; Masao Ohto; Akio Sakamoto; Eii Karasawa; Taketo Yamaguchi; Norihiro Shinozuka; Hui Zhu; Zhi-Biao Wanga
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Publication Detail:
Type:  Journal Article     Date:  2011-06-08
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  37     ISSN:  1879-291X     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-04     Completed Date:  2011-12-05     Revised Date:  2011-12-12    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1222-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
International HIFU Center, Naruto General Hospital, Sanbu-shi, Chiba, Japan.
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MeSH Terms
Aged, 80 and over
Carcinoma, Hepatocellular / therapy*,  ultrasonography
Contrast Media / diagnostic use
Ferric Compounds / diagnostic use
Gadolinium DTPA / diagnostic use
High-Intensity Focused Ultrasound Ablation / methods
Iron / diagnostic use
Liver Function Tests
Liver Neoplasms / therapy*,  ultrasonography
Magnetic Resonance Imaging
Oxides / diagnostic use
Tomography, X-Ray Computed
Treatment Outcome
Ultrasonography, Interventional
Reg. No./Substance:
0/Contrast Media; 0/Ferric Compounds; 0/Oxides; 0/Sonazoid; 0/gadolinium ethoxybenzyl DTPA; 7439-89-6/Iron; 80529-93-7/Gadolinium DTPA

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