Document Detail


Treatment-related Burkitt's lymphoma: literature review and case report of successful treatment with rituximab monotherapy.
MedLine Citation:
PMID:  19887777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of Burkitt's lymphoma (BL) is uncommon in elderly people. Most treatment-related hematological malignancies are of a myeloid lineage. Only a few cases with BL secondary to cancer treatment have been described. We report a rare case of an elderly patient with radiotherapy-related BL. A 71-year-old Japanese man, who had a past history of oropharyngeal cancer treated with local irradiation 15 years ago, presented with a left mandibular mass in December 2004. A partial mandibulectomy disclosed pathological features consistent with BL. Although the patient was initially treated with intensive chemotherapy, the development of complications precluded further anticancer drug treatment. Rituximab was administered once weekly for 5 consecutive weeks, with resolution of the mandibular mass. He remained in remission without further lymphoma treatment for more than 3 years after diagnosis. Rituximab monotherapy should be considered as a therapeutic option for elderly patients with BL.
Authors:
Akitoshi Nagasaki; Atsushi Yamanoha; Taeko Okudaira; Takashi Miyagi; Nobuyuki Takasu
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-10-29
Journal Detail:
Title:  Acta haematologica     Volume:  122     ISSN:  1421-9662     ISO Abbreviation:  Acta Haematol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-20     Completed Date:  2009-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  211-5     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Department of Endocrinology and Metabolism, Internal Medicine, University of the Ryukyus School of Medicine, Okinawa, Japan. anaga@ryudai2nai.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Antibodies, Monoclonal / therapeutic use*
Antineoplastic Agents / therapeutic use
Burkitt Lymphoma / etiology*,  pathology,  therapy*
Humans
Magnetic Resonance Imaging
Male
Mandibular Neoplasms / etiology,  pathology,  therapy
Neoplasms, Radiation-Induced / etiology,  pathology,  therapy*
Neoplasms, Second Primary / etiology*,  pathology,  therapy*
Oropharyngeal Neoplasms / radiotherapy
Remission Induction
Time Factors
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antineoplastic Agents; 0/rituximab

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