Document Detail


Treatment of Pseudomonas meningitis with ceftazidime with or without concurrent therapy.
MedLine Citation:
PMID:  2179845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In ongoing studies in Europe and the United States, 10 pediatric patients with bacterial meningitis caused by Pseudomonas species were treated with ceftazidime. Pseudomonas aeruginosa was isolated from the CSF of 7 patients and other Pseudomonas species from the remaining 3. Eight of the 10 patients had received previous antimicrobial treatment which included aminoglycosides in 6, along with ticarcillin and ureidopenicillins in 3. Ceftazidime was administered 10 to 42 days in dosages ranging from 109 to 300 mg/kg/day. Seven of the 10 patients received ceftazidime only for 10 to 42 days. The other 3 patients received amikacin in 2 and gentamicin and tobramycin in the other. Seven patients were cured clinically and 3 died; 9 were cured bacteriologically and one who was presumed cured on the basis of clinical response subsequently died. Sterilization of the cerebrospinal fluid occurred at 48 hours to 12 days. Ceftazidime appears useful in treating bacterial meningitis caused by Pseudomonas species.
Authors:
W J Rodriguez; W N Khan; D M Cocchetto; J Feris; J R Puig; S Akram
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  9     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-24     Completed Date:  1990-04-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Affiliation:
Children's Hospital National Medical Center, Washington, DC 20010.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Aminoglycosides
Anti-Bacterial Agents / therapeutic use
Ceftazidime / therapeutic use*
Drug Therapy, Combination / therapeutic use
Female
Humans
Infant
Infant, Newborn
Male
Meningitis / drug therapy*
Pseudomonas / isolation & purification
Pseudomonas Infections / drug therapy*
Chemical
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 78439-06-2/Ceftazidime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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