| Treatment of primary systemic vasculitis with the inosine monophosphate dehydrogenase inhibitor mycophenolic acid. | |
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MedLine Citation:
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PMID: 20484933 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Despite advances in the treatment of vasculitis, modern therapies fail to induce or maintain remission in a significant proportion of patients. Mycophenolic acid is increasingly used to treat vasculitis syndromes. Here, we consider relevant pharmacokinetic and pharmacodynamic properties of mycophenolate, with emphasis on the impact of renal impairment, and we review the existing evidence for and current trials of mycophenolate in the treatment of primary systemic vasculitides. |
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Authors:
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Thomas F Hiemstra; Rachel B Jones; David R W Jayne |
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Publication Detail:
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Type: Journal Article Date: 2010-05-12 |
Journal Detail:
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Title: Nephron. Clinical practice Volume: 116 ISSN: 1660-2110 ISO Abbreviation: Nephron Clin Pract Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101159763 Medline TA: Nephron Clin Pract Country: Switzerland |
Other Details:
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Languages: eng Pagination: c1-10 Citation Subset: IM |
Affiliation:
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Lupus and Vasculitis Unit, Addenbrookes Hospital, Cambridge, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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