Document Detail

Treatment of osteoarthritis of the ankle by intra-articular injections of hyaluronic acid: a prospective study.
MedLine Citation:
PMID:  20237359     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Treatment of osteoarthritis of the ankle is similar to that of any other large joint and includes conservative and surgical options. Surgical treatment in severe cases is fusion or joint replacement, whereas conservative treatment is limited and includes mainly ankle supports and physiotherapy. Hyaluronic acid was discovered by Meyer and Palmer in 1934 and has recently been widely used in the treatment of knee osteoarthritis. We evaluated the efficacy of an intra-articular preparation containing sodium hyaluronate in the treatment of osteoarthritis of the ankle. METHODS: We studied 16 patients aged 31 to 79 years (mean age, 43 years) with symptomatic ankle osteoarthritis of 9 months' to 27 years' duration. The radiographic severity of the ankle osteoarthritis was graded II, III, or IV according to Kellgren and Lawrence. Arthritic ankles underwent intra-articular injections of 25 mg of sodium hyaluronate for 5 consecutive weeks. Follow-up visits were performed 4, 8, 11, 17, and 32 weeks after treatment and included clinical evaluation and objective scoring. RESULTS: Global assessment showed improvement in 13 of 15 patients who completed the study. There was improvement by 20% in range of motion and a significant reduction in pain assessed by visual analog scale and ankle-hindfoot scores, all statistically significant. Seven months after treatment, no decrease in efficacy was shown. Two patients did not show any significant improvement in global assessment after treatment. One patient was dropped from follow-up owing to concurrent back surgery. CONCLUSIONS: Symptomatic relief of signs and symptoms of osteoarthritis of the ankle was achieved by injection of an intra-articular preparation containing sodium hyaluronate. There were significant improvements, in objective and subjective parameters, that lasted for more than 7 months. Ankle intra-articular injection of sodium hyaluronate is a valid conservative treatment for ankle osteoarthritis.
Omer Mei-Dan; Beni Kish; Shai Shabat; Sabri Masarawa; Avi Shteren; Gideon Mann; Meir Nyska
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Podiatric Medical Association     Volume:  100     ISSN:  1930-8264     ISO Abbreviation:  J Am Podiatr Med Assoc     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-03-18     Completed Date:  2010-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501423     Medline TA:  J Am Podiatr Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-100     Citation Subset:  IM    
Department of Orthopedic Surgery, Meir University Hospital, Kfar-Saba, Israel.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Dose-Response Relationship, Drug
Drug Administration Schedule
Follow-Up Studies
Hyaluronic Acid / administration & dosage*
Injections, Intra-Articular
Knee Joint / drug effects*,  physiopathology
Middle Aged
Osteoarthritis / drug therapy*,  radiography
Pain Measurement
Prospective Studies
Range of Motion, Articular / physiology
Risk Assessment
Severity of Illness Index
Single-Blind Method
Treatment Outcome
Reg. No./Substance:
9004-61-9/Hyaluronic Acid

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