Document Detail


Treatment for mechanical valve thrombosis in the right heart: combined pharmacological and mechanical thrombolysis.
MedLine Citation:
PMID:  20618228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report clinical results of combined pharmacological and mechanical thrombolysis for mechanical prosthetic valve thrombosis (PVT) in the right heart. Between January 1992 and December 2008, combined thrombolysis, which consisted of an intravenous infusion of urokinase together with mechanical disruption of thrombus in a prosthetic valve by temporarily increasing the cardiac pacing rate, was performed in three patients with four cases of mechanical PVT in the right heart. The prosthetic valve in all three patients was a bileaflet mechanical valve, and was located in the tricuspid position in two patients and in the pulmonary position in the remaining patient. PVT was diagnosed by echocardiography and cineradiography. Thrombolysis was successful in all four cases in the three patients, and no hemorrhagic complications or clinically symptomatic pulmonary embolisms were observed. Mechanical disruption of thrombus using a pacemaker appears to be an effective adjunctive modality to thrombolysis with fibrinolytic agents for PVT in the right heart. Combined pharmacological and mechanical thrombolysis may improve success rates and reduce the time required for thrombolysis of PVT.
Authors:
Shigeaki Aoyagi; Shuji Fukunaga; Hideki Teshima
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-07-06
Journal Detail:
Title:  Artificial organs     Volume:  34     ISSN:  1525-1594     ISO Abbreviation:  Artif Organs     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-11     Completed Date:  2010-11-24     Revised Date:  2010-12-29    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E238-41     Citation Subset:  IM    
Affiliation:
Department of Surgery, Kurume University School of Medicine, Kurume, Japan. aoyagi@med.kurume-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fibrinolytic Agents / therapeutic use*
Heart Catheterization*
Heart Valve Diseases / drug therapy,  etiology
Heart Valve Prosthesis / adverse effects*
Humans
Male
Middle Aged
Pulmonary Valve*
Thrombosis / drug therapy*,  etiology
Tricuspid Valve*
Young Adult
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents
Comments/Corrections
Comment In:
Artif Organs. 2010 Dec;34(12):1164; author reply 1165   [PMID:  21155847 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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