Document Detail


Treatment of Low HDL-C Subjects with the CETP Modulator Dalcetrapib Increases Plasma Campesterol Only in Those Without ABCA1 and/or ApoA1 Mutations.
MedLine Citation:
PMID:  25281277     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We investigated the effect of dalcetrapib treatment on phytosterol levels in patients with familial combined hyperlipidemia (FCH) or familial hypoalphalipoproteinemia (FHA) due to mutations in apolipoprotein A1 (ApoA1) or ATP-binding cassette transporter A1 (ABCA1). Patients (n = 40) with FCH or FHA received dalcetrapib 600 mg or placebo in this 4-week, double-blind, crossover study. Lipids, apolipoproteins, cholesteryl ester transfer protein (CETP) activity and mass, and phytosterols were assessed. Dalcetrapib increased high-density lipoprotein cholesterol (HDL-C) and ApoA1 levels to a similar extent in FHA (+22.8, +13.9 %) and FCH (+18.4, +12.1 %), both p < 0.001 vs. placebo. Changes in CETP activity and mass were comparable for FHA (-31.5, +120.9 %) and FCH (-26.6, +111.9 %), both p < 0.0001 vs. placebo. Campesterol and lathosterol were unchanged in FHA (+3.8, +3.0 %), but only campesterol was markedly increased in FCH (+25.0 %, p < 0.0001 vs. placebo). Campesterol increased with dalcetrapib treatment in FCH but not in FHA, despite comparable HDL-C and ApoA1 increases, suggesting that ApoA1 and/or ABCA1 is essential for HDL lipidation by enterocytes in humans.
Authors:
Eric J Niesor; David Kallend; Darren Bentley; John J P Kastelein; G Kees Hovingh; Erik S G Stroes
Related Documents :
22248997 - Tracking of leptin, soluble leptin receptor, and the free leptin index during weight lo...
8568857 - Differential effect of triiodothyronine and thyroxine on liposomes containing cholester...
14646197 - Cholesterol esterase bound to intestinal brush border membranes does not accelerate inc...
25411287 - Socioeconomic determinants of dietary patterns in low- and middle-income countries: a s...
9130027 - Reproducibility of anthropometric and body composition measurements: the heritage famil...
25049857 - The effects of rhodobacter capsulatus kctc-2583 on cholesterol metabolism, egg producti...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-4
Journal Detail:
Title:  Lipids     Volume:  -     ISSN:  1558-9307     ISO Abbreviation:  Lipids     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-4     Completed Date:  -     Revised Date:  2014-10-5    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison of the rhythm control treatment strategy versus the rate control strategy in patients wit...
Next Document:  Zaprinast impairs spatial memory by increasing PDE5 expression in the rat hippocampus.