| Treatment of IgA nephropathy of adults presented by nephrotic syndrome. | |
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MedLine Citation:
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PMID: 18816254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this retrospective study was to evaluate the results of the immunosuppressive regiment in managing of IgA nephropathy associated with primary nephrotic syndrome at the Nephrology Clinic, University of Sarajevo Clinics Centre in period of 1997-2007. We studied 19 patients (4 women and 15 men) with idiopathic nephrotic syndrome, where pathomorphologic changes of IgA nephropathy were proved by kidney biopsy. The levels of diuresis, proteinuria, albuminemia, lipidemia and kidney function, as measure of efficiency of used therapy, were monitored. The IgA nephropathy present with the nephrotic syndrome was shown in 15.8% (19) patients underwent renal biopsy due to primary nephrotic syndrome in the period of observation. The average age of patients with IgA nephropathy was 34.9+/-14.1 years. Eight patients from this group were treated with corticosteroid therapy (1-1.5 mg/kg of body weight for 4 weeks, followed by 0.5 mg/ kg of body weight until therapeutic response was achieved, and finally gradual exclusion of therapy after eight weeks in responsive patients), 6 patients with corticosteroids and bolus cyclophosphamide (10-15 mg/kg BW), and in 5/19 patients cyclosporine therapy was used (3 mg/kg BW). Complete remission of nephrotic syndrome was achieved in 42.1% of the patients. In conclusion, in adults patients with primary nephrotic syndrome associated with IgA nephropathy, used immunosuppressive therapy resulted in a high percentage of achieved remissions. |
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Authors:
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Senija Rasić; Snjezana Uncanin; Kenana Aganović; Ismar Rasić; Jasminka Dzemidzić; Alma Muslimović |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bosnian journal of basic medical sciences / Udruženje basičnih mediciniskih znanosti = Association of Basic Medical Sciences Volume: 8 ISSN: 1512-8601 ISO Abbreviation: Bosn J Basic Med Sci Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-09-25 Completed Date: 2008-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101200947 Medline TA: Bosn J Basic Med Sci Country: Bosnia and Hercegovina |
Other Details:
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Languages: eng Pagination: 230-3 Citation Subset: IM |
Affiliation:
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Nephrology Clinic, University of Sarajevo Clinics Centre, Bolnicka 25, 71000 Sarajevo, Bosnia and Herzegovina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use* Adult Biopsy Cyclophosphamide / administration & dosage, therapeutic use* Cyclosporine / therapeutic use* Dose-Response Relationship, Drug Drug Therapy, Combination Female Glomerulonephritis, IGA / drug therapy*, pathology Humans Immunosuppressive Agents / therapeutic use* Kidney / pathology Male Middle Aged Nephrotic Syndrome / drug therapy*, pathology Pulse Therapy, Drug Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide; 59865-13-3/Cyclosporine |
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