| Treatment of Hepatic Metastases from Gastric or Gastroesophageal Adenocarcinoma with Computed Tomography-guided High-dose-rate Brachytherapy (CT-HDRBT). | |
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MedLine Citation:
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PMID: 23225451 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: This retrospective analysis was performed to evaluate the clinical outcome of patients with hepatic metastases from gastric or gastroesophageal adenocarcinoma who were treated with computed tomography-guided high-dose-rate brachytherapy (CT-HDRBT). PATIENTS AND METHODS: Eight patients with a total number of 12 isolated hepatic metastases from histologically-proven adenocarcinoma of the lower oesophagus or stomach, were treated with CT-HDRBT. Gadoxetic acid-enhanced magnetic resonance imaging (MRI) was performed 6 and 12 weeks after CT-HDRBT and then every 3 months to evaluate treatment efficacy. RESULTS: The median follow-up time was 6.1±6.8 months. Lesion size ranged from 14 to 68 mm in diameter with a median of 46±21 mm. No patient developed a local recurrence. Five patients developed systemic progression after a median time of 3.7±3.6 months (three in the liver, one in liver and bone and one in liver and resection margin from gastrectomy). One patient died 3.4 months after CT-HDRBR because of liver progression with cholestasis. No major complications associated with the treatment occurred. CONCLUSION: CT-HDRBT might be a feasible alternative to surgical resection of liver metastases from gastric or gastroesophageal adenocarcinoma in selected patients and seems to have similar outcome rates as surgical resection in our small collective. |
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Authors:
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Dominik Geisel; Timm Denecke; Federico Collettini; Christian Grieser; Peter Wust; Peter Thuss-Patience; Bernd Hamm; Bernhard Gebauer |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 32 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 5453-8 Citation Subset: IM |
Affiliation:
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Department of Diagnostic and Interventional Radiology, Charité Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. dominik.geisel@charite.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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