Document Detail


Treatment of Graves' ophthalmopathy with cyclosporin A.
MedLine Citation:
PMID:  3840854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the effect of Cyclosporin A in the management of Graves' ophthalmopathy, we treated 13 patients with severe euthyroid endocrine eye disease with the immunosuppressive drug. Follow up consisted of clinical investigation, laboratory evaluation with detailed thyroid function tests and complete ophthalmological assessments including A and B scan ultrasound and computerized tomography (CT) of the orbits. Cyclosporin A given over 4-7 months resulted in improvement of clinical signs and symptoms of the disease due to a positive effect of the drug on soft tissue changes. The more objective methods did not demonstrate any unequivocal change in proptosis, visual acuity, intraocular pressure and thickness of extraocular muscles. Cyclosporin A was not able to stop acute progression of ophthalmopathy in one patient and did not obviate surgical decompression of the orbits in two more patients. There was no measurable effect of treatment on the underlying immunological process with regard to thyroid disease.
Authors:
A Witte; R Landgraf; A Markl; K P Boergen; G Hasenfratz; C R Pickardt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Klinische Wochenschrift     Volume:  63     ISSN:  0023-2173     ISO Abbreviation:  Klin. Wochenschr.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-01-09     Completed Date:  1986-01-09     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  2985205R     Medline TA:  Klin Wochenschr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1000-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cyclosporins / adverse effects,  therapeutic use*
Female
Follow-Up Studies
Graves Disease / drug therapy*,  radiography
Humans
Male
Middle Aged
Orbit / radiography
Thyroid Function Tests
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Cyclosporins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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