| Treatment of glaucoma in clinical practice: four-year results from a patient registry in France. | |
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MedLine Citation:
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PMID: 19661825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate long-term resource consumption and clinical outcome of patients with early primary open-angle glaucoma or ocular hypertension treated with prostaglandins in clinical practice in France. METHODS: Thirty-four geographically spread specialized hospitals and private practices enrolled consecutive patients receiving, for the first time, a prostaglandin, alone or in combination. The study was based on routine practice and no consultations, examinations, or treatments were mandated by the protocol. Treating physicians recorded each consultation, including all examinations performed, referrals, admissions, and prescriptions. Descriptive analysis of resource consumption and development of intraocular pressure (IOP) and visual fields was performed, for all patients who completed the 4-year follow-up. RESULTS: The study enrolled 602 patients and 78% completed 4-year follow-up. Mean age was 65 years and mean time since diagnosis was 4 years. Mean IOP was reduced from a baseline of 21.2 mm Hg to 16.5 mm Hg during the first year and remained stable throughout the study. Mean visual fields at baseline were -4.2 mean deviation and stable during the follow-up. Total mean health care costs per patient were €1947, of which medication represented 50%. Over half of the patients (52%) remained on their initial medication during the 4 years. Drug changes were mostly because of inadequate IOP control and the number of treatment switches was significantly related to costs. CONCLUSIONS: This is the first prospective study of treatment with prostaglandins in clinical practice. The results indicate that many patients with early glaucoma managed primarily with prostaglandins will show very little progression over 4 years. Compared with the mid-90s, costs have not increased despite the higher acquisition cost of prostaglandins, as surgical interventions and medical consultations have decreased. |
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Authors:
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Gisela Kobelt; Brigitte Texier-Richard; Patricia Buchholz; Alain Bron; Jean-Paul Renard; Jean-Francois Rouland; Jean-Philippe Nordmann |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of glaucoma Volume: 19 ISSN: 1536-481X ISO Abbreviation: J. Glaucoma Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9300903 Medline TA: J Glaucoma Country: United States |
Other Details:
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Languages: eng Pagination: 199-206 Citation Subset: IM |
Affiliation:
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European Health Economics, Speracedes, France. Gisela.kobelt@he-europe.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Amides / economics, therapeutic use Antihypertensive Agents / economics*, therapeutic use Cloprostenol / analogs & derivatives, economics, therapeutic use Cost-Benefit Analysis Drug Costs Female France Glaucoma, Open-Angle / drug therapy, economics*, physiopathology Health Care Costs* Health Resources / utilization Humans Intraocular Pressure / drug effects Male Middle Aged Ocular Hypertension / drug therapy, economics, physiopathology Prospective Studies Prostaglandins F, Synthetic / economics, therapeutic use Registries |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Antihypertensive Agents; 0/Prostaglandins F, Synthetic; 0/bimatoprost; 130209-82-4/latanoprost; 157283-68-6/travoprost; 40665-92-7/Cloprostenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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