Document Detail

Treatment of gingival recession defects using coronally advanced flap with a porcine collagen matrix compared to coronally advanced flap with connective tissue graft: a randomized controlled clinical trial.
MedLine Citation:
PMID:  21721988     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Connective tissue graft (CTG) plus coronally advanced flap (CAF) is the reference therapy for root coverage. The aim of the present study is to evaluate the use of a porcine collagen matrix (PCM) plus CAF as an alternative to CTG+CAF for the treatment of gingival recessions (REC), in a prospective randomized, controlled clinical trial.
METHODS: Eighteen adult patients participated in this study. The patients presented 22 single Miller's Class I or II REC, randomly assigned to the test (PCM+CAF) or control (CTG+CAF) group. REC, probing depth, clinical attachment level (CAL), and width of keratinized tissue (KG) were evaluated at 12 months. In addition, the gingival thickness (GT) was measured 1mm apical to the bottom of the sulcus.
RESULTS: At 12 months, mean REC was 0.23 mm for test sites and 0.09 mm for control sites (P <0.01), whereas percentage of root coverage was 94.32% and 96.97%, respectively. CAL gain was 2.41 mm in test sites and 2.95 mm in control sites (P <0.01). KG gain was 1.23 mm in the test group and 1.27 mm in the control group (P <0.01). In test sites, GT changed from 0.82 to 1.82 mm, and in control sites, from 0.86 to 2.09 mm (P <0.01).
CONCLUSIONS: Within the limits of the study, both treatment procedures resulted in significant reduction in REC at 12 months. No statistically significant differences were found between PCM+CAF and CTG+CAF with regard to any clinical parameter. The collagen matrix represents a possible alternative to CTG.
Daniele Cardaropoli; Lorenzo Tamagnone; Alessandro Roffredo; Lorena Gaveglio
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2011-07-01
Journal Detail:
Title:  Journal of periodontology     Volume:  83     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-01     Completed Date:  2012-08-13     Revised Date:  2013-02-06    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-8     Citation Subset:  D; IM    
PROED Professional Education in Dentistry, Turin, Italy.
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MeSH Terms
Collagen / therapeutic use*
Collagen Type I / therapeutic use
Collagen Type III / therapeutic use
Connective Tissue / transplantation
Follow-Up Studies
Gingiva / pathology,  transplantation*
Gingival Recession / classification,  surgery*
Membranes, Artificial*
Middle Aged
Periodontal Attachment Loss / surgery
Periodontal Pocket / surgery
Prospective Studies
Surgical Flaps*
Tooth Root / pathology,  surgery
Young Adult
Reg. No./Substance:
0/Collagen Type I; 0/Collagen Type III; 0/Membranes, Artificial; 68238-35-7/Keratins; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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