| Treatment of GERD complications (Barrett's, peptic stricture) and extra-oesophageal syndromes. | |
| | |
MedLine Citation:
|
PMID: 21126707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Apart from typical reflux symptoms and oesophagitis, the clinical presentation of GERD can be dominated by mucosal complications of reflux (Barrett's oesophagus, oesophageal adenocarcinoma, Peptic structure) or by extra-oesophageal syndromes, most notably asthma, laryngitis, or chronic cough. Managing these entities is much less straightforward than with oesophagitis. With respect to adenocarcinoma, metaplasia and dysplasia are recognised precursors, but the potential of these lesions to evolve to cancer has not been shown to lessen as a result of treatment, medical or surgical. Consequently, management focuses on strategies to identify and eliminate high-grade dysplasia and intramucosal cancer, lesions that are potentially curable by endoscopic ablation or surgical resection. With respect to the extra-oesophageal GERD syndromes, these are increasingly recognised as multifactorial conditions with reflux as an exacerbating factor. Treatment trials have been generally disappointing and the clinical challenge remains in accurately identifying afflicted patients who might benefit from more intensive medical or surgical reflux treatment. |
| | |
Authors:
|
Ajay Bansal; Peter J Kahrilas |
Related Documents
:
|
6615287 - Carotid body tumor associated with partial horner's syndrome and facial pain ('raeder's... 18971877 - Encephalopathy and mri abnormalities in fat embolism syndrome: a case report. 8916567 - Ciliospinal reflex response in cluster headache. 18454417 - False negative apraclonidine test in two patients with horner syndrome. 22544447 - Polyneuropathy associated with the diffuse infiltrative lymphocytosis syndrome. 11326487 - Fibromyalgia syndrome and serotonin. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Best practice & research. Clinical gastroenterology Volume: 24 ISSN: 1532-1916 ISO Abbreviation: Best Pract Res Clin Gastroenterol Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-03 Completed Date: 2011-03-21 Revised Date: 2011-12-21 |
Medline Journal Info:
|
Nlm Unique ID: 101120605 Medline TA: Best Pract Res Clin Gastroenterol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 961-8 Citation Subset: IM |
Copyright Information:
|
Published by Elsevier Ltd. |
Affiliation:
|
Department of Medicine, Veterans Affairs Medical Center, University of Kansas, MO, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma
/
etiology,
therapy* Asthma / etiology, therapy Barrett Esophagus / etiology, therapy* Cough / etiology, therapy Dilatation Esophageal Neoplasms / etiology, therapy* Esophageal Stenosis / etiology, therapy* Esophagoscopy Gastroesophageal Reflux / complications, therapy* Humans Laryngitis / etiology, therapy Proton Pump Inhibitors / therapeutic use Stents Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
|
R01 DK056033-09/DK/NIDDK NIH HHS; R01 DK56033/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Proton Pump Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Surgical therapy of gastro-oesophageal reflux disease.
Next Document: Ensocopic-endoluminal therapies. A critical appraisal.