| Treatment of fungal keratitis from Fusarium infection by corneal cross-linking. | |
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MedLine Citation:
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PMID: 22081155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the efficacy of corneal cross-linking (CXL) (riboflavin-UV-A) as a simple therapy in Fusarium keratitis. METHODS: Twenty-four rabbits were systemically anesthetized, and the stromata of their right corneas were inoculated with Fusarium solani [10(5) colony-forming units (CFU) per milliliter]. Rabbits were divided into 2 groups: one was treated with CXL 72 hours after infection and the other did not receive any treatment (control). All eyes in both the groups were examined before (days 0 and 3) and after (day 7) CXL treatment. The eyes were enucleated, and corneal buttons were sent for microbiological and histological examinations. RESULTS: All animals developed Fusarium keratitis; there was no statistically significant difference between groups before treatment (day 0, P = 0.397 and day 3, P = 0.702). After CXL treatment, the difference in clinical scores on day 7 between groups was statistically significant (P = 0.00); the CXL group showed significant lower clinical score. The CXL group had 22.45 ± 5.09 CFU/g compared with 42.5 ± 3.12 CFU/g in the control group; this difference was statistically significant (P = 0.01). In the 3 buttons of the control group, similar amounts of Fusarium hyphae and inflammatory cells were observed. In 2 of the 3 buttons analyzed from the CXL group, fewer Fusarium hyphae, inflammatory cells, and nonspecific stromal changes were observed compared with the control group. CONCLUSIONS: Treatment of fungal keratitis with CXL seems to be effective in decreasing the intensity and severity of infectious keratitis by F. solani. This therapy may be useful as a coadjuvant in the medical treatment of resistant infections. |
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Authors:
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Gustavo Galperin; Martín Berra; Julia Tau; Gabriela Boscaro; Jorge Zarate; Alejandro Berra |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cornea Volume: 31 ISSN: 1536-4798 ISO Abbreviation: Cornea Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-16 Completed Date: 2012-03-06 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 176-80 Citation Subset: IM |
Affiliation:
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Laboratorio de Investigaciones Oculares, Buenos Aires, Argentina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Colony Count, Microbial Disease Models, Animal Eye Infections, Fungal / microbiology, radiotherapy* Fusariosis / microbiology, radiotherapy* Fusarium / isolation & purification Keratitis / microbiology, radiotherapy* Photosensitizing Agents / therapeutic use Rabbits Riboflavin / therapeutic use Ultraviolet Therapy* |
| Chemical | |
Reg. No./Substance:
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0/Photosensitizing Agents; 83-88-5/Riboflavin |
| Comments/Corrections | |
Comment In:
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Cornea. 2013 Feb;32(2):218
[PMID:
23172118
]
Cornea. 2013 Feb;32(2):217-8 [PMID: 23086375 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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