| Treatment of Frey's syndrome with topical 2% diphemanil methylsulfate (Prantal): a double-blind evaluation of 15 patients. | |
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MedLine Citation:
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PMID: 2190054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifteen patients with severe gustatory sweating after total parotidectomy and facial nerve preservation were asked to take part in a double-blind study. All patients were alternatively treated with topically applied placebo and topically applied 2% diphemanil methylsulfate (an anticholinergic agent). A 10-day period was allowed between applications for return of symptoms. Two-percent diphemanil methylsulfate provided partial relief in 33.3% of patients and total relief in 40% of patients. Involvement of the hairy temporal line region with gustatory sweating was the main reason for failure. Duration of relief varied from 2 to 4 days. The only side effect was dryness of the mouth noted in two patients. |
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Authors:
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O Laccourreye; B Bonan; D Brasnu; H Laccourreye |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: The Laryngoscope Volume: 100 ISSN: 0023-852X ISO Abbreviation: Laryngoscope Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-07-12 Completed Date: 1990-07-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 651-3 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology-Head and Neck Surgery Hopital Laennec, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Aged Clinical Trials as Topic Double-Blind Method Female Humans Male Middle Aged Parasympatholytics / administration & dosage*, therapeutic use Piperidines / administration & dosage*, therapeutic use Sweating, Gustatory / drug therapy*, surgery |
| Chemical | |
Reg. No./Substance:
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0/Parasympatholytics; 0/Piperidines; 62-97-5/diphemanil methylsulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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