| Treatment of Frey's syndrome with botulinum toxin type B. | |
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MedLine Citation:
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PMID: 20647122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Frey's syndrome is a frequent sequela of parotidectomy, causing facial sweating and flushing because of gustatory stimuli. Although botulinum toxin type A has become first-line therapy for Frey's syndrome, some patients become resistant. In this study, we investigated whether another serotype, botulinum toxin type B, might be an effective alternative. STUDY DESIGN: Case series with planned data collection. SETTING: Otolaryngology department in a university hospital. SUBJECTS AND METHODS: Seven patients aged 30 to 68 years, with severe Frey's syndrome, underwent the Minor test and had 80 U of botulinum toxin type B per cm(2) (mean total dose, 2354 U) injected intracutaneously in the mapped area of gustatory sweating. All patients were followed up for 12 months. RESULTS: One month after treatment, six of the seven patients reported that gustatory sweating and flushing had resolved, and, in the remaining patient, these symptoms had decreased. The Minor test confirmed a significant improvement. The subjective benefits remained stable for six months in four patients and for nine months in the remaining three patients; 12 months after treatment, all patients still reported some improvement. CONCLUSION: Botulinum toxin type B afforded symptomatic relief in a small sample of patients with Frey's syndrome and might be considered a potential alternative to botulinum toxin type A. |
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Authors:
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Giovanna Cantarella; Alessandra Berlusconi; Vincenzo Mele; Filippo Cogiamanian; Sergio Barbieri |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Volume: 143 ISSN: 1097-6817 ISO Abbreviation: Otolaryngol Head Neck Surg Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508176 Medline TA: Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 214-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Otolaryngology, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy. giovanna.cantarella@policlinico.mi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Dyskinesia Agents / therapeutic use* Botulinum Toxins / therapeutic use* Female Humans Injections, Intradermal Male Middle Aged Parotid Gland / surgery Questionnaires Statistics, Nonparametric Sweating, Gustatory / drug therapy*, etiology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Dyskinesia Agents; 0/Botulinum Toxins; 0/botulinum toxin type B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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