| Treatment of FLT3-ITD Positive Acute Myeloid Leukemia Relapsing After Allogeneic Stem Cell Transplantation with Sorafenib. | |
| | |
MedLine Citation:
|
PMID: 21767516 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Patients with acute myeloid leukemia (AML) and internal tandem duplication of Fms-like tyrosine kinase receptor-3 gene (FLT3-ITD) mutation have poor prognosis and are often treated with allogeneic hematopoietic stem cell transplantation (HSCT). Sorafenib, an inhibitor of multiple kinases including FLT3, has shown promising activity in FLT3-ITD positive AML. We treated 16 patients with FLT3-ITD positive AML who relapsed after HSCT with sorafenib alone (n=8) or in combination with cytotoxic chemotherapy (n=8). The number of circulating blasts decreased in 80% of cases, but none of the patients achieved complete remission; three achieved partial remission. Two patients were bridged to a second transplant but both relapsed within 3 months of the transplant. Median overall survival was 83 days with none surviving more than a year. Sorafenib is not effective in the treatment of FLT3-ITD positive AML relapsing after HSCT. Preventive strategies after HSCT may be more suitable for these high-risk patients. |
| | |
Authors:
|
Manish Sharma; Farhad Ravandi; Ulas Darda Bayraktar; Alexandre Chiattone; Qaiser Bashir; Sergio Giralt; Julianne Chen; Muzaffar Qazilbash; Partow Kebriaei; Marina Konopleva; Michael Andreeff; Jorge Cortes; Deborah McCue; Hagop Kantarjian; Richard E Champlin; Marcos de Lima |
Related Documents
:
|
22182636 - Co-transplantation of macaque autologous schwann cells and human embryonic nerve stem c... 5031656 - Pharmacodynamics of propranolol in renal failure. 22172836 - Lipid profile changes during the first year after kidney transplantation: risk factors ... 22270186 - Performance of the japanese gfr equation in potential kidney donors. 8614256 - Is hypothalamic prostaglandin e2 involved in avian fever? 15281496 - Recombinant factor viia for life-threatening bleeding in high-risk cardiac surgery desp... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-15 |
Journal Detail:
|
Title: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Volume: - ISSN: 1523-6536 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9600628 Medline TA: Biol Blood Marrow Transplant Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
|
Department of Stem Cell Transplantation. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term Outcome of Patients with Metastatic Breast Cancer Treated with High-Dose Chemotherapy and ...
Next Document: Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes.