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Treatment of FLT3-ITD Positive Acute Myeloid Leukemia Relapsing After Allogeneic Stem Cell Transplantation with Sorafenib.
MedLine Citation:
PMID:  21767516     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Patients with acute myeloid leukemia (AML) and internal tandem duplication of Fms-like tyrosine kinase receptor-3 gene (FLT3-ITD) mutation have poor prognosis and are often treated with allogeneic hematopoietic stem cell transplantation (HSCT). Sorafenib, an inhibitor of multiple kinases including FLT3, has shown promising activity in FLT3-ITD positive AML. We treated 16 patients with FLT3-ITD positive AML who relapsed after HSCT with sorafenib alone (n=8) or in combination with cytotoxic chemotherapy (n=8). The number of circulating blasts decreased in 80% of cases, but none of the patients achieved complete remission; three achieved partial remission. Two patients were bridged to a second transplant but both relapsed within 3 months of the transplant. Median overall survival was 83 days with none surviving more than a year. Sorafenib is not effective in the treatment of FLT3-ITD positive AML relapsing after HSCT. Preventive strategies after HSCT may be more suitable for these high-risk patients.
Authors:
Manish Sharma; Farhad Ravandi; Ulas Darda Bayraktar; Alexandre Chiattone; Qaiser Bashir; Sergio Giralt; Julianne Chen; Muzaffar Qazilbash; Partow Kebriaei; Marina Konopleva; Michael Andreeff; Jorge Cortes; Deborah McCue; Hagop Kantarjian; Richard E Champlin; Marcos de Lima
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-15
Journal Detail:
Title:  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation     Volume:  -     ISSN:  1523-6536     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9600628     Medline TA:  Biol Blood Marrow Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Department of Stem Cell Transplantation.
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