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Treatment of Erythema Migrans With Doxycycline for 10 Days Versus 15 Days.
MedLine Citation:
PMID:  22523260     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BackgroundThe efficacy of 10-day doxycycline treatment in erythema migrans patients has been assessed in the USA but not in Europe. Experts disagree on the significance of post-Lyme borreliosis symptoms.MethodsIn a non-inferiority trial 10-day or 15-day oral doxycycline was evaluated for treatment efficacy in adult European patients with erythema migrans. The prevalence of nonspecific symptoms was compared between erythema migrans patients and 80 control subjects without a history of Lyme borreliosis. Efficacy of treatment based on clinical observations and microbiologic testing was assessed at 14 days and at 2, 6, and 12 months. Nonspecific symptoms in patients and controls were compared at 6 months post-enrollment.Results117 (52%) patients were treated with doxycycline for 15 days and 108 (48%) with doxycycline for 10 days. At 12 months post-enrollment, 85/91 (93.4%) patients in the 15-day group and 79/86 (91.9%) in the 10-day group had complete response (1.6% percentage point difference, upper limit of 95% CI 9.1%). At 6 months, the frequency of nonspecific symptoms in the patients was similar to that among controls.ConclusionsThe 10-day regimen with oral doxycycline is not inferior to the 15-day regimen in treatment of adult European patients with solitary erythema migrans. Six months after treatment the frequency of nonspecific symptoms in erythema migrans patients is similar to that in control subjects.Registered at: http://clinicaltrials.gov, Identifier NCT00910715.
Authors:
Dasa Stupica; Lara Lusa; Eva Ruzic-Sabljic; Tjasa Cerar; Franc Strle
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-20
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  -     ISSN:  1537-6591     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Infectious Diseases, University Medical Center Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia.
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