Document Detail


Treatment of Chronic Hypercalcemia.
MedLine Citation:
PMID:  22571196     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hypercalcemia is a relatively frequent alteration, mostly associated to primary hyperparathyroidism (PHPT) and malignancy-associated hypercalcemia (MAH). Treatment first includes rehydration and loop diuretics, as general measures. Bisphosphonates are considered the drugs of choice due to their long-term management. Calcitonin is preferable in the short-term control of severe hypercalcemia. The antireabsorptive action of bisphosphonates has been considered the most effective in the disorders characterized by an excessive bone resorption. Zoledronate is superior to both clodronate or pamidronate in the treatment of MAH. Calcimimetic agents has been recently introduced to control hypercalcemia in selected cases of PHPT. They are used when surgery is not possible or patients do not meet surgical criteria. Malignancy-associate hypercalcemia is broadly divided into two categories: humoral MAH and osteolytic MAH. The first concerns the paraneoplastic release of humoral factors, mainly parathyroid hormone-related peptide (PTHrP). Recently a humanized monoclonal antibody against human PTHrP has been generated and is still under evaluation. The receptor activator of nuclear factor-κ ligand (RANKL) has a critical role in the etiology of malignancy skeletal complications. The fully humanized anti-RANKL antibody (denosumab) would seem to be even more effective than bisphosphonates to suppress bone resorption, as shown in preliminary results .
Authors:
V Camozzi; G Luisetto; S M M Basso; P Cappelletti; R Tozzoli; F Lumachi
Related Documents :
24492026 - Development of a tick-borne encephalitis serodiagnostic elisa using recombinant fc-anti...
7507516 - Antibodies to myelin/oligodendrocyte-specific protein and myelin/oligodendrocyte glycop...
25048126 - Computational prediction of b cell epitopes from antigen sequences.
23725156 - Inhibition by imatinib of expression of o-glycan-related glycosyltransferases and tumor...
3576076 - Immunochemical studies of microsomal membranes of rat preneoplastic and neoplastic hepa...
9797366 - Lack of correlation between lewis antigen expression by helicobacter pylori and gastric...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-4
Journal Detail:
Title:  Medicinal chemistry (Shariqah (United Arab Emirates))     Volume:  -     ISSN:  1875-6638     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101240303     Medline TA:  Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medical & Surgical Sciences, University of Padua, School of Medicine, via Giustiniani 2, 35128 Padova, Italy; E-mail: camozzina@camozzina.it.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Treatment of Acute Hypercalcemia.
Next Document:  TGF-? sensitivity is determined by N-linked glycosylation of the type II TGF-? receptor.