Document Detail


Treatment of Cardiotonic Pills(®) after Ischemia-Reperfusion Ameliorates Myocardial Fibrosis in Rats.
MedLine Citation:
PMID:  22913380     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The present study was designed to evaluate whether CP was beneficial for alleviating myocardial fibrosis following I/R injury. METHODS: Sprague-Dawley rats were subjected to 30 min occlusion of the left anterior descending coronary artery, followed by reperfusion. CP (0.4 or 0.8 g/kg) was daily administrated starting from 3 h after reperfusion until day 6. Coronary venular diameter, RBC velocity, albumin leakage, MBF, heart function, myocardial infarction and fibrosis size, myocardium ultrastructure, MPO activity and MDA level were evaluated. The expression of MCP-1, RP S19, TGF-β1, P-Smad3, Smad4, MMP-9 and α-SMA, and the infiltration of leukocytes were examined. RESULTS: CP post-treatment ameliorated I/R-induced myocardial RBC velocity reduction, MBF decrease, cardiac dysfunction, and albumin leakage increase. Moreover, myocardial infarction and fibrosis size, MPO activity, MDA level, the expression of RP S19, TGF-β1, P-Smad3, Smad4, MMP-9 and α-SMA, the number of CD68-positive cells increased significantly after I/R, and myocardium collagen deposition was observed on day 6 after reperfusion. All the alterations after I/R were significantly ameliorated by CP. CONCLUSIONS: Post-treatment with CP ameliorates I/R induced myocardial fibrosis, suggesting that CP may be applied as an option for preventing cardiac remodeling after I/R injury. © 2012 John Wiley & Sons Ltd.
Authors:
Xiao-Hong Wei; Yu-Ying Liu; Quan Li; Li Yan; Bai-He Hu; Chun-Shui Pan; Zhi-Xin Li; Xin Chang; Jing-Yu Fan; Na Zhao; Kai Sun; Ping Huang; Chuan-She Wang; Tai-Ping Fan; Jing-Yan Han
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-22
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  -     ISSN:  1549-8719     ISO Abbreviation:  Microcirculation     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons Ltd.
Affiliation:
Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chinese, Medicine of the People's, Republic of China.
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