| Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study. | |
| | |
MedLine Citation:
|
PMID: 22936007 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
This pilot, double-blind, placebo-controlled, randomized, escalating dose trial explored the safety and efficacy of tideglusib, an inhibitor of glycogen synthase kinase-3, in Alzheimer's disease (AD) patients. Thirty mild-moderate AD patients on cholinesterase inhibitor treatment were administered escalating doses (400, 600, 800, 1,000 mg) of tideglusib or placebo (ratio 2 : 1) for 4, 4, 6, and 6 weeks, respectively. The primary objective was to evaluate the safety and tolerability of tideglusib with strict criteria for drug escalation or withdrawal. Mini-Mental Status Examination (MMSE), Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog+), word fluency, Geriatric Depression Scale (GDS), and a final Global Clinical Assessment (GCA) were assessed as secondary objectives. Treatment was well tolerated. Adverse events were as frequent in active and placebo groups, except for some moderate, asymptomatic, and fully reversible increases (>2.5 × ULN) of serum transaminases in 6 active cases (p = 0.001). Tideglusib produced positive trends in MMSE, ADAS-cog, GDS, and GCA without statistical significance in this small sample. Responders in MMSE were significantly higher in the active group (p = 0.05). Patients escalated up to 1000 mg/day had a benefit of increases of 1.68 points in the MMSE and 4.72 points in the ADAS-cog+ when compared to placebo. This small pilot study provides valuable safety and efficacy estimates for the treatment of AD patients with tideglusib, currently being confirmed in a larger clinical trial. Due to escalating doses and the small sample size, this trial provides insufficient evidence to support or reject a benefit of tideglusib in AD. |
| | |
Authors:
|
Teodoro Del Ser; Klaus C Steinwachs; Hermann J Gertz; María V Andrés; Belén Gómez-Carrillo; Miguel Medina; Joan A Vericat; Pilar Redondo; David Fleet; Teresa León |
Related Documents
:
|
9440297 - Affect, cognition, and the emergence of self-knowledge in the toddler offspring of depr... 9271977 - Depression after childbirth: the views of medical students and women compared. 16195287 - Effect of sublingual misoprostol on severe postpartum haemorrhage in a primary health c... 23242697 - Correlates of self-reported depressive symptoms: a study of older persons of punjab, pa... 14584007 - Depot risperidone for schizophrenia. 9807637 - Clinical utility of the selective serotonin reuptake inhibitors in the spectrum of anxi... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-30 |
Journal Detail:
|
Title: Journal of Alzheimer's disease : JAD Volume: - ISSN: 1875-8908 ISO Abbreviation: J. Alzheimers Dis. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9814863 Medline TA: J Alzheimers Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Noscira SA, Madrid, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intracellular Degradation of Misfolded Tau Protein Induced by Geldanamycin is Associated with Activa...
Next Document: Longitudinal Stability Evaluation of Biomarkers and Their Correlation in Cerebrospinal Fluid and Pla...