| Treatment for 24 months with recombinant human GH has a beneficial effect on bone mineral density in young adults with childhood-onset GH deficiency. | |
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MedLine Citation:
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PMID: 19324976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Discontinuation of growth hormone (GH) therapy on completion of linear growth may adversely affect bone mineral density (BMD) in young adults with childhood-onset GH-deficiency (GHD). In the present study, we analyzed the impact of GH treatment on bone in young adults with GHD. METHODS: BMD at the lumbar spine (L2-L4), total hip, and total body was measured at baseline and after 24 months in a cohort of young adults (18-25 years; n=160) with severe GHD treated with GH during childhood who were randomized to GH (n=109) or no treatment (n=51) in a multicenter, multinational, open-label study. GH starting doses (0.2 mg/day (males), 0.4 mg/day (females)) were increased after 1 month to 0.6 mg/day (males) and 0.9 mg/day (females) and then to 1.0 mg/day (males) and 1.4 mg/day (females) at 3 months for the remainder of the study. RESULTS: After 24 months, lumbar spine BMD had increased significantly more in GH-treated patients than in controls (6 vs 2%; estimated treatment difference; 3.5% (95% confidence interval, 1.52-5.51) P<0.001). GH also had a significant positive effect on total hip BMD (P=0.015). Total body BMD was unchanged from baseline (P=0.315). CONCLUSIONS: In young adults treated for childhood-onset GHD, there is a beneficial effect of continued GH treatment on BMD in adult life. Twenty-four months of GH treatment in these young adults was associated with an estimated 3.5% greater increase in BMD of the lumbar spine compared with controls. |
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Authors:
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G S Conway; M Szarras-Czapnik; K Racz; A Keller; P Chanson; M Tauber; M Zacharin; |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-03-26 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 160 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-12 Completed Date: 2009-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 899-907 Citation Subset: IM |
Affiliation:
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Department of Endocrinology and Diabetes, University College London Hospitals, 250 Euston Road, London NW1 2PQ, UK. g.conway@ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adolescent Adult Age of Onset Alkaline Phosphatase / metabolism Bone Density Bone Remodeling / physiology* Bone and Bones / metabolism Female Growth Disorders / drug therapy* Human Growth Hormone / adverse effects, deficiency*, therapeutic use* Humans Insulin-Like Growth Factor I / metabolism Male Recombinant Proteins / adverse effects, therapeutic use* Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I; EC 3.1.3.1/Alkaline Phosphatase |
| Investigator | |
Investigator/Affiliation:
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Timothy Jones / ; Rob Johnston / ; Glynic Price / ; Martin Epstein / ; Margaret Zacharin / ; Fergus Cameron / ; Ian Holdaway / ; Andrew Grey / ; Dominique Maiter / ; Rolf-Christian Gaillard / ; Anna Maria De Luca / ; Primus Mullis / ; Udo Meinhart / ; Sara Bachmann / ; Heinz Tschaeppeler / ; Kurt Lippuner / ; Rainer Wolf / ; Andreas Giger / ; Marianne Rohrbach / ; Jean-Marc Vuissoz / ; Eberhard Keller / ; Alexandra Keller / ; Antonio Carrascosa / ; Diego Yeste / ; Phillipe Chanson / ; Thierry Brue / ; Maïthé Tauber / ; Gerry Conway / ; Alison Sturrock / ; John Connell / ; Faisel Ahmed / ; Károly Rácz / ; Nokolette Szucs / ; Gyori Gabriella / ; Csaba Horváth / ; Agnes Mondok / ; Miklós Góth / ; László Kovács / ; Erica Hubina / ; Gudmundur Johansson / ; Johan Svensson / ; Tomasz Romer / ; Maria Szarras-Czapnik / ; Urszula Oczkowska / ; Jerzy Starzyk / ; Agata Górska / ; Dominika Januś / ; Anna Kalicka-Kasperczyk / ; Malgorzata Kumorowicz-Kopiec / ; Aleksandra Górska / ; Katarzyna Dolezal-Oltarzewska / ; Dorota Roztoczańska / ; Joann Wojtyś / ; Edyta Pietkowska / ; Barbara Krzyzanowska-Siniarska / ; Jaroslaw Ogonoswki / ; Tomasz Miazgowski / ; Maria Korpal-Szczyrska / ; Bohdana Dorant / ; Halina Kamińska / ; Dorota Birkholtz / ; Ludomira Rzepecka Wejs / ; Krystyna Turek / ; Ewa Barg / ; Beata Wikiera / ; Diana Jedrzejczuk / ; Jens Bollerslev / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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