Document Detail


Treatment for 24 months with recombinant human GH has a beneficial effect on bone mineral density in young adults with childhood-onset GH deficiency.
MedLine Citation:
PMID:  19324976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Discontinuation of growth hormone (GH) therapy on completion of linear growth may adversely affect bone mineral density (BMD) in young adults with childhood-onset GH-deficiency (GHD). In the present study, we analyzed the impact of GH treatment on bone in young adults with GHD. METHODS: BMD at the lumbar spine (L2-L4), total hip, and total body was measured at baseline and after 24 months in a cohort of young adults (18-25 years; n=160) with severe GHD treated with GH during childhood who were randomized to GH (n=109) or no treatment (n=51) in a multicenter, multinational, open-label study. GH starting doses (0.2 mg/day (males), 0.4 mg/day (females)) were increased after 1 month to 0.6 mg/day (males) and 0.9 mg/day (females) and then to 1.0 mg/day (males) and 1.4 mg/day (females) at 3 months for the remainder of the study. RESULTS: After 24 months, lumbar spine BMD had increased significantly more in GH-treated patients than in controls (6 vs 2%; estimated treatment difference; 3.5% (95% confidence interval, 1.52-5.51) P<0.001). GH also had a significant positive effect on total hip BMD (P=0.015). Total body BMD was unchanged from baseline (P=0.315). CONCLUSIONS: In young adults treated for childhood-onset GHD, there is a beneficial effect of continued GH treatment on BMD in adult life. Twenty-four months of GH treatment in these young adults was associated with an estimated 3.5% greater increase in BMD of the lumbar spine compared with controls.
Authors:
G S Conway; M Szarras-Czapnik; K Racz; A Keller; P Chanson; M Tauber; M Zacharin;
Related Documents :
5018716 - Oral contraceptives and tryptophan metabolism: effects of oestrogen in low dose combine...
8878716 - Factors associated with withdrawal bleeding after administration of oral dydrogesterone...
18174716 - Introduction and management of puberty in girls.
12730626 - Effects of exogenous estrogenic agents on pubertal growth and reproductive system matur...
6890446 - The effect of an alpha-ketoglutarate-pyridoxine complex on human maximal aerobic and an...
6130456 - Tracheal relaxant and cardiostimulant actions of xanthines can be differentiated from d...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-03-26
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  160     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-12     Completed Date:  2009-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  899-907     Citation Subset:  IM    
Affiliation:
Department of Endocrinology and Diabetes, University College London Hospitals, 250 Euston Road, London NW1 2PQ, UK. g.conway@ucl.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Adolescent
Adult
Age of Onset
Alkaline Phosphatase / metabolism
Bone Density
Bone Remodeling / physiology*
Bone and Bones / metabolism
Female
Growth Disorders / drug therapy*
Human Growth Hormone / adverse effects,  deficiency*,  therapeutic use*
Humans
Insulin-Like Growth Factor I / metabolism
Male
Recombinant Proteins / adverse effects,  therapeutic use*
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I; EC 3.1.3.1/Alkaline Phosphatase
Investigator
Investigator/Affiliation:
Timothy Jones / ; Rob Johnston / ; Glynic Price / ; Martin Epstein / ; Margaret Zacharin / ; Fergus Cameron / ; Ian Holdaway / ; Andrew Grey / ; Dominique Maiter / ; Rolf-Christian Gaillard / ; Anna Maria De Luca / ; Primus Mullis / ; Udo Meinhart / ; Sara Bachmann / ; Heinz Tschaeppeler / ; Kurt Lippuner / ; Rainer Wolf / ; Andreas Giger / ; Marianne Rohrbach / ; Jean-Marc Vuissoz / ; Eberhard Keller / ; Alexandra Keller / ; Antonio Carrascosa / ; Diego Yeste / ; Phillipe Chanson / ; Thierry Brue / ; Maïthé Tauber / ; Gerry Conway / ; Alison Sturrock / ; John Connell / ; Faisel Ahmed / ; Károly Rácz / ; Nokolette Szucs / ; Gyori Gabriella / ; Csaba Horváth / ; Agnes Mondok / ; Miklós Góth / ; László Kovács / ; Erica Hubina / ; Gudmundur Johansson / ; Johan Svensson / ; Tomasz Romer / ; Maria Szarras-Czapnik / ; Urszula Oczkowska / ; Jerzy Starzyk / ; Agata Górska / ; Dominika Januś / ; Anna Kalicka-Kasperczyk / ; Malgorzata Kumorowicz-Kopiec / ; Aleksandra Górska / ; Katarzyna Dolezal-Oltarzewska / ; Dorota Roztoczańska / ; Joann Wojtyś / ; Edyta Pietkowska / ; Barbara Krzyzanowska-Siniarska / ; Jaroslaw Ogonoswki / ; Tomasz Miazgowski / ; Maria Korpal-Szczyrska / ; Bohdana Dorant / ; Halina Kamińska / ; Dorota Birkholtz / ; Ludomira Rzepecka Wejs / ; Krystyna Turek / ; Ewa Barg / ; Beata Wikiera / ; Diana Jedrzejczuk / ; Jens Bollerslev /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Protection from lipopolysaccharide-induced lung injury by augmentation of airway S-nitrosothiols.
Next Document:  What does a structured review of the effectiveness of exercise interventions for persons with multip...