Document Detail

Treating restless legs syndrome: current pathophysiological concepts and clinical trials.
MedLine Citation:
PMID:  11922859     Owner:  NLM     Status:  MEDLINE    
Restless legs syndrome is a distinctive clinical syndrome with a prevalence of about 5% in the general population. One of the outstanding characteristics of restless legs syndrome is its extreme responsiveness to dopaminergic agents. Together with the latest pathophysiological and genetic findings, recent epidemiological and clinical data give a new insight into the classification of restless legs syndrome, thus building the theoretical foundation for the development of new pharmacological methods in its treatment. Current efforts within this area focus on establishing dopaminergic substances for therapy. The hypothesis of a disturbed iron metabolism in restless legs syndrome has been revived by recent theoretical considerations. The present review attempts to explain current strategies of treatment for restless legs syndrome in relation to aetiological, genetic and pathophysiological findings.
Björn Wito Walther
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  11     ISSN:  1354-3784     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-29     Completed Date:  2002-08-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  501-14     Citation Subset:  IM    
Department of Neurology, HELIOS Klinikum Erfurt, P.O. Box 101263, 99012 Erfurt, Germany.
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MeSH Terms
Brain / physiopathology
Clinical Trials as Topic
Disease Models, Animal
Dopamine Agonists / therapeutic use*
Iron / metabolism
Restless Legs Syndrome / drug therapy*,  genetics,  metabolism,  physiopathology
Reg. No./Substance:
0/Dopamine Agonists; 7439-89-6/Iron

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