Document Detail

Treating onychomycosis.
MedLine Citation:
PMID:  11237081     Owner:  NLM     Status:  MEDLINE    
Onychomycosis accounts for one third of fungal skin infections. Because only about one half of nail dystrophies are caused by fungus, the diagnosis should be confirmed by potassium hydroxide preparation, culture or histology before treatment is started. Newer, more effective antifungal agents have made treating onychomycosis easier. Terbinafine and itraconazole are the therapeutic agents of choice. Although the U.S. Food and Drug Administration has not labeled fluconazole for the treatment of onychomycosis, early efficacy data are promising. Continuous oral terbinafine therapy is most effective against dermatophytes, which are responsible for the majority of onychomycosis cases. Intermittent pulse dosing with itraconazole is as safe and effective as short-term continuous therapy but more economical and convenient. With careful monitoring, patients treated with the newer antifungal agents have a good chance of achieving relief from onychomycosis and its complications.
P Rodgers; M Bassler
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American family physician     Volume:  63     ISSN:  0002-838X     ISO Abbreviation:  Am Fam Physician     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-09     Completed Date:  2001-03-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1272646     Medline TA:  Am Fam Physician     Country:  United States    
Other Details:
Languages:  eng     Pagination:  663-72, 677-8     Citation Subset:  AIM; IM    
University of Michigan Medical School, Ann Arbor, USA.
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MeSH Terms
Antifungal Agents / economics,  therapeutic use*
Clinical Trials as Topic
Combined Modality Therapy
Diagnosis, Differential
Drug Costs
Drug Interactions
Fluconazole / therapeutic use
Itraconazole / therapeutic use
Naphthalenes / therapeutic use
Onychomycosis / classification,  diagnosis,  drug therapy*,  economics
Patient Education as Topic
Teaching Materials
Treatment Failure
Reg. No./Substance:
0/Antifungal Agents; 0/Naphthalenes; 84625-61-6/Itraconazole; 86386-73-4/Fluconazole; 91161-71-6/terbinafine
Erratum In:
Am Fam Physician 2001 Jun 1;63(11):2129

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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