| Treating heart failure with sildenafil. | |
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MedLine Citation:
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PMID: 19627292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sildenafil is a selective inhibitor of type 5 phosphodiesterase, the main phosphodiesterase isoform responsible for hydrolysis of intracellular cyclic guanosine monophosphate in the pulmonary vasculature. It improves exercise capacity and quality of life in patients with systolic heart failure, especially in those who develop secondary pulmonary hypertension. It improves peak oxygen consumption, reduces minute ventilation/carbon dioxide output slope, and acts as a selective pulmonary vasodilator during rest and exercise in patients with heart failure and pulmonary hypertension. It improves flow-mediated maximal dilatation, ergoreflex on ventilation, and breathlessness both after 3 and 6 months of treatment. Sildenafil, by improving endothelial activity and muscle perfusion, improves signaling and ventilatory efficiencies, potentially indicating a novel approach in the therapeutic management of heart failure. |
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Authors:
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Arnon Blum |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Congestive heart failure (Greenwich, Conn.) Volume: 15 ISSN: 1751-7133 ISO Abbreviation: Congest Heart Fail Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-07-24 Completed Date: 2009-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9714174 Medline TA: Congest Heart Fail Country: United States |
Other Details:
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Languages: eng Pagination: 181-5 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Baruch-Padeh Poria Medical Center, Lower Galilee, Israel. navablum@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity
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drug effects Heart Failure / complications, drug therapy* Hemodynamics / drug effects Humans Hypertension, Pulmonary / drug therapy, etiology Muscle, Smooth / drug effects Oxygen Consumption / drug effects Phosphodiesterase Inhibitors / therapeutic use* Piperazines / therapeutic use* Purines / therapeutic use Quality of Life Reflex / drug effects Sulfones / therapeutic use* Systole |
| Chemical | |
Reg. No./Substance:
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0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 139755-83-2/sildenafil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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