Document Detail


Treating ectopic pregnancy with the combination of mifepristone and methotrexate: a phase II nonrandomized study.
MedLine Citation:
PMID:  9757964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Our goal was to compare the use of a combination of methotrexate and mifepristone with methotrexate alone in the medical management of ectopic pregnancy. STUDY DESIGN: This was a preliminary nonrandomized phase II study. All patients with progressing ectopic pregnancy meeting criteria for medical management were included. Treatment consisted of 50 mg/m2 of methotrexate injected intramuscularly and 600 mg of mifepristone, administered orally, compared with a previous group who received only 50 mg/m2 of methotrexate injected intramuscularly. RESULTS: Of the 30 patients treated with the combination, there was only 1 failure, whereas medical treatment had failed for 11 of 42 patients treated with methotrexate alone. CONCLUSIONS: The combination of mifepristone and methotrexate decreased the risk of failure in medical treatment of ectopic pregnancy.
Authors:
M Perdu; E Camus; P Rozenberg; F Goffinet; C Chastang; H J Philippe; I Nisand
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase II; Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  179     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-22     Completed Date:  1998-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  640-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Gynecology and Obstetrics, Poissy Hospital, University of Paris V, France.
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents, Steroidal / therapeutic use*
Adult
Chorionic Gonadotropin / blood
Drug Therapy, Combination
Female
Humans
Methotrexate / therapeutic use*
Mifepristone / therapeutic use*
Pregnancy
Pregnancy, Ectopic / blood,  drug therapy*
Risk
Treatment Failure
Chemical
Reg. No./Substance:
0/Abortifacient Agents, Steroidal; 0/Chorionic Gonadotropin; 59-05-2/Methotrexate; 84371-65-3/Mifepristone
Comments/Corrections
Comment In:
Am J Obstet Gynecol. 1999 Jun;180(6 Pt 1):1599-600   [PMID:  10368554 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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