| Treating ectopic pregnancy with the combination of mifepristone and methotrexate: a phase II nonrandomized study. | |
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MedLine Citation:
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PMID: 9757964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our goal was to compare the use of a combination of methotrexate and mifepristone with methotrexate alone in the medical management of ectopic pregnancy. STUDY DESIGN: This was a preliminary nonrandomized phase II study. All patients with progressing ectopic pregnancy meeting criteria for medical management were included. Treatment consisted of 50 mg/m2 of methotrexate injected intramuscularly and 600 mg of mifepristone, administered orally, compared with a previous group who received only 50 mg/m2 of methotrexate injected intramuscularly. RESULTS: Of the 30 patients treated with the combination, there was only 1 failure, whereas medical treatment had failed for 11 of 42 patients treated with methotrexate alone. CONCLUSIONS: The combination of mifepristone and methotrexate decreased the risk of failure in medical treatment of ectopic pregnancy. |
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Authors:
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M Perdu; E Camus; P Rozenberg; F Goffinet; C Chastang; H J Philippe; I Nisand |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase II; Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 179 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-10-22 Completed Date: 1998-10-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 640-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Gynecology and Obstetrics, Poissy Hospital, University of Paris V, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Steroidal
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therapeutic use* Adult Chorionic Gonadotropin / blood Drug Therapy, Combination Female Humans Methotrexate / therapeutic use* Mifepristone / therapeutic use* Pregnancy Pregnancy, Ectopic / blood, drug therapy* Risk Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Steroidal; 0/Chorionic Gonadotropin; 59-05-2/Methotrexate; 84371-65-3/Mifepristone |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 1999 Jun;180(6 Pt 1):1599-600
[PMID:
10368554
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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