| Treating chemotherapy induced agranulocytosis with granulocyte colony-stimulating factors in a patient on clozapine. | |
| | |
MedLine Citation:
|
PMID: 23059755 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Clozapine is reserved for overcoming treatment resistance in schizophrenia. Malignancy is common in schizophrenia; however, there is limited evidence available on continuing clozapine with chemotherapy, with both having hematological adverse effects. OBJECTIVE: To report a case on the use of granulocyte colony-stimulating factor (G-CSF) in conjunction with clozapine and chemotherapy. METHODS: We searched PubMed for any available information on the use of granulocyte G-CSF with clozapine and chemotherapy. We report the case of a patient with schizophrenia who developed B-cell lymphoma and was treated with chemotherapy consisting of CHOP regimen, rituximab, and methotrexate. He was continued on clozapine and G-CSF. RESULTS: We did not find any reports on G-CSF use in conjunction with clozapine and chemotherapy. We found case reports and a case series on the use of G-CSF in clozapine rechallenge with clozapine-induced agranulocytosis with mixed results. In our patient on clozapine, the white blood cell counts reduced by chemotherapy, were successfully replenished with the use of filgrastim, a G-CSF. CONCLUSIONS: With risks of psychosis relapse and exacerbation with discontinuing clozapine, the addition of G-CSF could be a useful aid in replenishing white cell counts lost to chemotherapy whilst continuing clozapine. However, further study is needed on this combination. Copyright © 2012 John Wiley & Sons, Ltd. |
| | |
Authors:
|
Venkata Kolli; Kevin Denton; Dileep Borra; Madhuri Pulluri; Ashish Sharma |
Related Documents
:
|
23106545 - Superselective intra-arterial chemotherapy for laryngeal preservation in carcinoma of t... 17388865 - Efficacy of aprepitant in management of chemotherapy-induced nausea and vomiting. 6470755 - Combination metoclopramide and dexamethasone: an effective antiemetic regimen in outpat... 23255905 - Second-line chemotherapy for refractory small cell neuroendocrine carcinoma of the esop... 9949295 - Elevation of the pacing threshold: a side effect in a patient with pacemaker undergoing... 17932895 - Study of radiolabeled indium-111 and yttrium-90 ibritumomab tiuxetan in primary central... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-12 |
Journal Detail:
|
Title: Psycho-oncology Volume: - ISSN: 1099-1611 ISO Abbreviation: Psychooncology Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9214524 Medline TA: Psychooncology Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 John Wiley & Sons, Ltd. |
Affiliation:
|
Creighton-Nebraska Psychiatry Residency Program, Omaha, NE, USA. kollivb@googlemail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of silver nanoparticles and silver nitrate in the earthworm reproduction test.
Next Document: Equivalence of a single dose (1200 mg) compared to a 3-time a day dose (400 mg) of chondroitin 4&6 s...