| Treating acute coronary syndromes with new antiplatelet drugs: the mortality issue with prasugrel and ticagrelor. | |
| | |
MedLine Citation:
|
PMID: 21919581 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract Acute coronary syndromes (ACS) are the leading cause of mortality in Western countries. Until a few years ago, the antiplatelet drug to be administered in association with aspirin was indisputably clopidogrel. Recent data from randomized trials conducted in ACS patients have shown that the new oral antiplatelet regimens, prasugrel and ticagrelor, are associated with a significant reduction in cardiovascular events, as compared to clopidogrel. Moreover ticagrelor reduced both all-cause and cardiovascular mortality as compared to clopidogrel in the PLATO trial. However, there are intrinsic differences between the trials design and among the enrolled ACS populations, that make complex the generalization of the mortality results in the whole spectrum of ACS patients. We aimed to provide further insights into the unresolved mortality issues raised in the PLATO and TRITON-TIMI 38 trials, by analysing the effects of ticagrelor and prasugrel in the ACS populations included in the respective trials. |
| | |
Authors:
|
Stefano De Servi; Eliano Pio Navarese; Maurizio D'Urbano; Stefano Savonitto |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-15 |
Journal Detail:
|
Title: Current medical research and opinion Volume: - ISSN: 1473-4877 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0351014 Medline TA: Curr Med Res Opin Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Cardiovascular Diseases, Legnano Hospital , Legnano (Milan) , Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selection for early response to photostimulation in broiler breeders.
Next Document: Memory for actions in autism spectrum disorder.