Document Detail


Treadmill running and swimming imposes distinct cardiovascular physiological adaptations in the rat: focus on serotonergic and sympathetic nervous systems modulation.
MedLine Citation:
PMID:  19009912     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Physical exercise may improve the metabolic and haemodynamic responses, but the beneficial effects seem to depend on intensity, duration and muscular mass recruitment, which may vary between different types of protocols. This study was performed to evaluate the effects of two distinct moderate/long-term aerobic training protocols in the normal Wistar rat, the treadmill running and the swimming, on several important parameters related to cardiovascular (CV) physiological adaptations, namely: lipid profile, haemorheological measures, lipid peroxidation, peripheral serotonergic system (SS) modulation and sympathetic nervous system (SNS) activation. In both groups under training an HDL-c increment versus the sedentary control was demonstrated. There was a noticeable increase in ADP-induced platelet aggregation in the exercised rats, together with higher PDW and MPV values. The RBC patterns were altered in both groups under training; in the swimming one, however, significantly higher RBC and HCT and lower MCH and MCHC values were found, suggesting renovation of the RBCs. Plasma and platelet SS measures were generally higher in both groups under training, being noticeably relevant the 5-HT and 5-HIAA increment in the treadmill. In opposition, concerning the plasma and platelet NE and E concentrations, the rise was remarkably higher in the rats under a swimming protocol. In conclusion, this study demonstrates that, despite the similar beneficial effects on lipid profile, different aerobic exercise protocols may produce distinct CV physiological adaptations. Therefore, treadmill running was more influent than swimming concerning peripheral SS modulation while swimming was more important on SNS activation, thus recommending a judicious choice of the protocol to be tested in works which make use of rat models of exercise to study physiological or pathophysiological conditions.
Authors:
S Baptista; N Piloto; F Reis; E Teixeira-de-Lemos; A P Garrido; A Dias; M Lourenço; A Palmeiro; C Ferrer-Antunes; F Teixeira
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  95     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2008-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  365-81     Citation Subset:  IM    
Affiliation:
Therapeutics Unit, Institute of Pharmacology and Experimental Therapeutics, Medicine Faculty, Coimbra University, 3000-354 Coimbra, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology*
Adrenal Glands / anatomy & histology,  metabolism
Animals
Aorta / anatomy & histology,  metabolism
Blood Platelets / metabolism
Cardiovascular System / innervation
Epinephrine / blood,  metabolism
Exercise Test
Heart / anatomy & histology,  physiology
Hemodynamics / physiology
Hydroxyindoleacetic Acid / blood,  metabolism
Lipid Peroxidation / physiology
Lipids / blood
Male
Norepinephrine / blood,  metabolism
Organ Size
Physical Conditioning, Animal / physiology
Platelet Aggregation / physiology
Rats
Rats, Wistar
Running / physiology*
Serotonin / blood*,  metabolism
Swimming / physiology*
Sympathetic Nervous System / physiology*
Chemical
Reg. No./Substance:
0/Lipids; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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