Document Detail

Treadmill running reverses retention deficit induced by morphine.
MedLine Citation:
PMID:  16549061     Owner:  NLM     Status:  MEDLINE    
Human and animal studies have suggested that exercise has benefits overall health and cognitive function. The aim of this study was to investigate the effect of treadmill running on passive avoidance learning and memory deficit in morphine-treated rats. The passive avoidance learning was measured in different time intervals (1, 2 and 24 h as well as 1 week and 1 month). Four groups of rats were included as follows: control, morphine-treated, exercised-saline and exercised-morphine-treated group. The electrical foot shock and treadmill training (2 h at a speed of 5 m/min for 10 days) were applied for all the groups. The data obtained was analyzed using unpaired Students t-test and ANOVA test with group as the independent variable, and performance in each session (avoidances and crossings) as the dependent variables. The results show that the total time staying in dark box was decreased in exercised-saline and exercised-morphine-treated rats by treadmill running (P<0.05). The avoidance learning was significantly reduced in morphine-treated group as indicated by the increased total time of staying in the dark box compared with the control group (P<0.05). We could conclude that exercise increased the delay time of entry to the dark electrical foot shock box, suggesting that morphine impaired the short-term memory and learning and this was reversed by the treadmill running.
Hojjatallah Alaei; Lila Borjeian; Mohammad Azizi; Shahrbanoo Orian; Aliasghar Pourshanazari; Osmo Hanninen
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-03-06
Journal Detail:
Title:  European journal of pharmacology     Volume:  536     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-07-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  138-41     Citation Subset:  IM    
Department of Physiology, Esfahan University of Medical Sciences, Iran.
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MeSH Terms
Analgesics, Opioid / administration & dosage,  toxicity
Analysis of Variance
Avoidance Learning / physiology
Behavior, Animal / physiology
Memory Disorders / chemically induced,  physiopathology*
Morphine / administration & dosage,  toxicity*
Physical Conditioning, Animal / physiology*
Physical Exertion / physiology*
Rats, Wistar
Substance Withdrawal Syndrome / etiology,  physiopathology
Time Factors
Reg. No./Substance:
0/Analgesics, Opioid; 57-27-2/Morphine

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