Document Detail

Treadmill running improves spatial memory in an animal model of Alzheimer's disease.
MedLine Citation:
PMID:  20709113     Owner:  NLM     Status:  In-Process    
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized by a decline in cognitive function and severe neuronal loss in the cerebral cortex and certain subcortical regions of the brain including nucleus basalis magnocellularis (NBM) that play an important role in learning and memory. There are few therapeutic regimens that influence the underlying pathogenic phenotypes of AD, however, of the currently available therapies, exercise training is considered to be one of the best strategies for attenuating the pathological phenotypes of AD for people with AD. Here, we sought to investigate the effect of treadmill running on spatial memory in Alzheimer-induced rats. Male Wistar rats were split into two groups namely shams (n=7) and lesions with the lesion group subdivided further into the lesion-rest (n=7) and lesion-exercise (n=7). The lesion-exercise and shams were subjected to treadmill running at 17 meters per minute (m/min) for 60 min per day (min/day), 7 days per week (days/wk), for 60 days. Spatial memory was investigated using the Morris Water Maze test in the rats after 60 days of Alzheimer induction and the exercise. Our data demonstrated that spatial memory was indeed impaired in the lesion group compared with the shams. However, exercise notably improved spatial memory in the lesion-exercised rats compared to lesion-rested group. The present results suggest that spatial memory is affected under Alzheimer conditions and that treadmill running improves these effects. Our data suggested that treadmill running contributes to the alleviation of the cognitive decline in AD.
Reihaneh Hoveida; Hojjatallah Alaei; Shahrbanoo Oryan; Kazem Parivar; Parham Reisi
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Publication Detail:
Type:  Journal Article     Date:  2010-08-13
Journal Detail:
Title:  Behavioural brain research     Volume:  216     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  270-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran 99999, Iran.
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