Document Detail

Treadmill exercise suppresses ischemia-induced increment in apoptosis and cell proliferation in hippocampal dentate gyrus of gerbils.
MedLine Citation:
PMID:  12954454     Owner:  NLM     Status:  MEDLINE    
Cerebral ischemia resulting from transient or permanent occlusion of cerebral arteries leads to neuronal cell death and eventually causes neurological impairments. In the present study, the effects of treadmill exercise on apoptosis and cell proliferation in the hippocampal dentate gyrus following transient global ischemia in gerbils were investigated using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay and immunohistochemistry for caspase-3 and 5-bromo-2'-deoxyuridine (BrdU). It was shown that apoptotic cell death and cell proliferation in the hippocampal dentate gyrus were significantly increased following transient global ischemia in gerbils and that treadmill exercise suppressed the ischemia-induced increase in apoptosis and cell proliferation in the dentate gyrus. The present results suggest that treadmill exercise may protect cells from apoptotic death and aid in recovery from the central nervous system sequelae following stroke.
Myoung-Hwa Lee; Hong Kim; Sung-Soo Kim; Taeck-Hyun Lee; Baek-Vin Lim; Hyun-Kyung Chang; Mi-Hyeon Jang; Min-Chul Shin; Mal-Soon Shin; Chang-Ju Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  73     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-04     Completed Date:  2003-09-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2455-65     Citation Subset:  IM    
Research Institute of Sports Science, Korea University, #1 5-Ka Anam-dong, Sungbuk-ku, Seoul 136-701 South Korea.
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MeSH Terms
Apoptosis / physiology*
Cell Division / physiology
Dentate Gyrus / pathology*
Disease Models, Animal
In Situ Nick-End Labeling
Ischemic Attack, Transient / pathology,  physiopathology*
Physical Conditioning, Animal
Physical Exertion*

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