Document Detail


Treadmill exercise reduces self-administration of morphine in male rats.
MedLine Citation:
PMID:  19131225     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Exercise can activate the same pathways as morphine. The aim of the present study was to clarify the effect of short-term and mid-term exercises on the self-administration of morphine in rats. Male Wistar rats were initially trained to receive small pellets of food by pressing the active lever in self-administration apparatus. Rats were divided into 4 groups: Saline, Morphine, Exercise 1 (11 days) and Exercise 2 (30 days). Their jugular vein was cannulated. The animals were placed in self-administration apparatus and allowed to self-administer morphine (0.5mg per infusion all test groups) or saline (Saline group) during consecutive days, for 2h/sessions. In the group 1 the rats were running before each session of self-administration and of group Exercise 2, 30 days before surgery as well as before each session. The pressing numbers of active and passive levers in each group and among different groups were compared. The number of active lever pressing of Morphine group was significantly higher than Saline group (p<0.001). In Exercise 1 and Exercise 2 groups, the number of active lever pressing was significantly lower than Morphine group (p<0.001). As exercise can activate many neurotransmitter systems involved in the addiction process and increase the release of endorphins, it is likely that could decrease the morphine self-administration in this experimental setup.
Authors:
Mahmoud Hosseini; Hojjat Allah Alaei; Asieh Naderi; Mohammad Reza Sharifi; Reza Zahed
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Publication Detail:
Type:  Journal Article     Date:  2009-01-07
Journal Detail:
Title:  Pathophysiology : the official journal of the International Society for Pathophysiology / ISP     Volume:  16     ISSN:  0928-4680     ISO Abbreviation:  Pathophysiology     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433813     Medline TA:  Pathophysiology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3-7     Citation Subset:  -    
Affiliation:
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
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