Document Detail

Treadmill exercise counteracts the suppressive effects of peripheral lipopolysaccharide on hippocampal neurogenesis and learning and memory.
MedLine Citation:
PMID:  17953674     Owner:  NLM     Status:  MEDLINE    
New neurons are continuously generated in hippocampal subgranular zone throughout life, and the amount of neurogenesis is suggested to be correlated with the hippocampus-dependent function. Several extrinsic stimuli are known to modulate the neurogenesis process. Among them, physical exercise has advantageous effects on neurogenesis and brain function, while inflammation shows the opposite. Herein we showed that a moderate running exercise successfully restored the peripheral lipopolysaccharide (LPS)-impaired neurogenesis in the dentate area. LPS treatment obstructed neuronal differentiation, but not proliferation. Exercise training facilitated both the proliferation of the neural stem cells and their differentiation into neurons. Interestingly, exercise replenished the LPS-reduced levels of brain-derived neurotrophic factor and its receptor, TrkB, and rescued the LPS-disturbed performance in water maze; while the LPS-elicited up-regulation of tumor necrosis factor-alpha and interleukin-1beta remained unaltered. In conclusion, our findings suggest that running exercise effectively ameliorates the LPS-disturbed hippocampal neurogenesis and learning and memory performance. Such advantageous effects of running exercise are not due to the alteration of inflammatory response, but possibly by the restoring the LPS-lessened brain-derived neurotrophic factor signaling pathway.
Chih-Wei Wu; Yi-Chieh Chen; Lung Yu; Hsiun-ing Chen; Chauying J Jen; A-Min Huang; Hsing-Jung Tsai; Ya-Ting Chang; Yu-Min Kuo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-22
Journal Detail:
Title:  Journal of neurochemistry     Volume:  103     ISSN:  1471-4159     ISO Abbreviation:  J. Neurochem.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-11     Completed Date:  2008-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  2471-81     Citation Subset:  IM    
Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan.
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MeSH Terms
Cell Differentiation / physiology
Cell Proliferation*
Encephalitis / chemically induced,  metabolism,  therapy*
Exercise Test
Exercise Therapy / methods*
Hippocampus / cytology,  physiopathology*
Inflammation Mediators / pharmacology
Learning / physiology
Lipopolysaccharides / pharmacology
Memory / physiology
Memory Disorders / chemically induced,  physiopathology,  therapy
Mice, Inbred C57BL
Neuronal Plasticity / physiology*
Neurons / physiology
Physical Conditioning, Animal / physiology*
Stem Cells / physiology
Reg. No./Substance:
0/Inflammation Mediators; 0/Lipopolysaccharides

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